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            <PreferredName>Single lesion</PreferredName>
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              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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            <CUI>C0577304</CUI>
            <PreferredName>Single lesion</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
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          <Object charOffset="14" text="single brain lesion">
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="VERB" charOffset="34" text="received" />
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            <CUI>C0034618</CUI>
            <PreferredName>Radiation therapy</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="98" text="brain">
            <CUI>C0006104</CUI>
            <PreferredName>Brain</PreferredName>
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              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="104" text="lesion">
            <CUI>C0221198</CUI>
            <PreferredName>Lesion</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
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          <Subject charOffset="131" text="WBRT">
            <CUI>C1520143</CUI>
            <PreferredName>Whole-Brain Radiotherapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
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            <CUI>C0034618</CUI>
            <PreferredName>Radiation therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="8" text="RESULTS: Both sequential treatments relieved neurological symptoms of more than 80% of patients.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="36" text="relieved" />
          <Subject charOffset="14" text="sequential treatments">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
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            <PreferredName>Neurologic Symptoms</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="66" text="of" />
          <Subject charOffset="45" text="neurological symptoms">
            <CUI>C0235031</CUI>
            <PreferredName>Neurologic Symptoms</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="87" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="13" text="Myelosuppression was the main concentration-dependent toxicity.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="17" text="was" />
          <Subject charOffset="0" text="Myelosuppression">
            <CUI>C0854467</CUI>
            <PreferredName>Myelosuppression</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="54" text="toxicity">
            <CUI>C0600688</CUI>
            <PreferredName>toxic effect</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="16" text="CONCLUSION: Both sequential treatments can be safely performed for SCLC patients with brain metastases, may relieve neurological symptoms, and well control both primary and metastatic lesions.">
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        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="62" text="for" />
          <Subject charOffset="17" text="sequential treatments">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="67" text="SCLC">
            <CUI>C0149925</CUI>
            <PreferredName>Small cell carcinoma of lung</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="80" text="with" />
          <Subject charOffset="86" text="brain metastases">
            <CUI>C0220650</CUI>
            <PreferredName>Metastatic malignant neoplasm to brain</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="COEXISTS_WITH" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="86" text="brain metastases">
            <CUI>C0220650</CUI>
            <PreferredName>Metastatic malignant neoplasm to brain</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="67" text="SCLC">
            <CUI>C0149925</CUI>
            <PreferredName>Small cell carcinoma of lung</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="17" text="sequential treatment">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="67" text="SCLC">
            <CUI>C0149925</CUI>
            <PreferredName>Small cell carcinoma of lung</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="17" text="sequential treatment">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="86" text="brain metastases">
            <CUI>C0220650</CUI>
            <PreferredName>Metastatic malignant neoplasm to brain</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="108" text="relieve" />
          <Subject charOffset="17" text="sequential treatment">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="116" text="neurological symptoms">
            <CUI>C0235031</CUI>
            <PreferredName>Neurologic Symptoms</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="148" text="control" />
          <Subject charOffset="17" text="sequential treatment">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="173" text="metastatic lesions">
            <CUI>C1513183</CUI>
            <PreferredName>Metastatic Lesion</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="148" text="control" />
          <Subject charOffset="17" text="sequential treatment">
            <CUI>C1519252</CUI>
            <PreferredName>Sequential Treatment</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="161" text="primary">
            <CUI>C1402294</CUI>
            <PreferredName>Primary Lesion</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15623373">
    <Sentence section="abstract" number="2" text="METHODS: Primary HCC patients who underwent tumor resection were retrospectively analyzed.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="9" text="Primary HCC">
            <CUI>C0019204</CUI>
            <PreferredName>Primary carcinoma of the liver cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="21" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="34" text="underwent" />
          <Subject charOffset="50" text="resection">
            <CUI>C0728940</CUI>
            <PreferredName>Excision</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="21" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="50" text="resection">
            <CUI>C0728940</CUI>
            <PreferredName>Excision</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="9" text="Primary HCC">
            <CUI>C0019204</CUI>
            <PreferredName>Primary carcinoma of the liver cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="10" text="CONCLUSION: The expressions of c-Myc, Ki-67, MMP-2 and VEGF in cancer tissues of the patients are related to the recurrence of their HCC after tumor resection.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="70" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Subject>
          <Object charOffset="63" text="cancer">
            <CUI>C0006826</CUI>
            <PreferredName>Malignant Neoplasms</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="77" text="of" />
          <Subject charOffset="70" text="tissue">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Subject>
          <Object charOffset="85" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="NOM" charOffset="16" text="expressions" />
          <Subject charOffset="31" text="c-Myc">
            <CUI>C0080065</CUI>
            <PreferredName>Proto-Oncogene Proteins c-myc</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="4609" name="MYC" />
            </EntrezGene>
          </Subject>
          <Object charOffset="70" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="NOM" charOffset="16" text="expressions" />
          <Subject charOffset="38" text="Ki-67">
            <CUI>C1334508</CUI>
            <PreferredName>MKI67 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="70" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="NOM" charOffset="16" text="expressions" />
          <Subject charOffset="45" text="MMP-2">
            <CUI>C0172537</CUI>
            <PreferredName>Gelatinase A</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="70" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="NOM" charOffset="16" text="expressions" />
          <Subject charOffset="55" text="VEGF">
            <CUI>C0078058</CUI>
            <PreferredName>Vascular Endothelial Growth Factor A</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="7422" name="VEGFA" />
            </EntrezGene>
          </Subject>
          <Object charOffset="70" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="149" text="resection">
            <CUI>C0728940</CUI>
            <PreferredName>Excision</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="143" text="tumor">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRECEDES" indicatorType="PREP" charOffset="136" text="after" />
          <Subject charOffset="149" text="resection">
            <CUI>C0728940</CUI>
            <PreferredName>Excision</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="133" text="HCC">
            <CUI>C0019204</CUI>
            <PreferredName>Primary carcinoma of the liver cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15634358">
    <Sentence section="title" number="1" text="The genetics of ray pattern variation in Caenorhabditis briggsae.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="37" text="in" />
          <Subject charOffset="4" text="genetics">
            <CUI>C0017399</CUI>
            <PreferredName>genetic aspects</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="41" text="Caenorhabditis briggsae">
            <CUI>C0997972</CUI>
            <PreferredName>Caenorhabditis briggsae</PreferredName>
            <SemanticTypes>
              <SemanticType>Invertebrate</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Invertebrate</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15653714">
    <Sentence section="abstract" number="7" text="Even for substantial changes in P(a,CO2), the two methods resulted in similar results." />
    <Sentence section="abstract" number="10" text="Haemodilution influences the two methods differently causing relative overestimation of blood flow by the laser Doppler technique compared to the 1(33)xenon method." />
  </MedlineCitation>
  <MedlineCitation pmid="15676161">
    <Sentence section="abstract" number="2" text="Asymptomatic patients are discovered incidentally during cardiac surgery for an unrelated condition or postmortem.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="0" text="Asymptomatic">
            <CUI>C0231221</CUI>
            <PreferredName>Asymptomatic</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
          </Subject>
          <Object charOffset="13" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="3" text="However, symptomatic patients may experience non-exertional paroxysmal stabbing chest pain.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="VERB" charOffset="34" text="experience" />
          <Subject charOffset="80" text="chest pain">
            <CUI>C0008031</CUI>
            <PreferredName>Chest Pain</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="21" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15722357">
    <Sentence section="abstract" number="3" text="Herein we describe the binding of three structurally diverse lipophilic drugs, bezafibrate, ibuprofen (both R- and S-isomers) and nitrazepam to I-FABP.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="NOM" charOffset="23" text="binding" />
          <Subject charOffset="79" text="bezafibrate">
            <CUI>C0005330</CUI>
            <PreferredName>Bezafibrate</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="144" text="I-FABP">
            <CUI>C0163314</CUI>
            <PreferredName>Fatty Acid-Binding Proteins, Intestinal-Specific</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="NOM" charOffset="23" text="binding" />
          <Subject charOffset="92" text="ibuprofen">
            <CUI>C0020740</CUI>
            <PreferredName>Ibuprofen</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="144" text="I-FABP">
            <CUI>C0163314</CUI>
            <PreferredName>Fatty Acid-Binding Proteins, Intestinal-Specific</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="NOM" charOffset="23" text="binding" />
          <Subject charOffset="130" text="nitrazepam">
            <CUI>C0028126</CUI>
            <PreferredName>Nitrazepam</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="144" text="I-FABP">
            <CUI>C0163314</CUI>
            <PreferredName>Fatty Acid-Binding Proteins, Intestinal-Specific</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="77" text="," />
          <Subject charOffset="79" text="bezafibrate">
            <CUI>C0005330</CUI>
            <PreferredName>Bezafibrate</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="drugs">
            <CUI>C0013227</CUI>
            <PreferredName>Pharmaceutical Preparations</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="77" text="," />
          <Subject charOffset="92" text="ibuprofen">
            <CUI>C0020740</CUI>
            <PreferredName>Ibuprofen</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="drugs">
            <CUI>C0013227</CUI>
            <PreferredName>Pharmaceutical Preparations</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="77" text="," />
          <Subject charOffset="130" text="nitrazepam">
            <CUI>C0028126</CUI>
            <PreferredName>Nitrazepam</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="drugs">
            <CUI>C0013227</CUI>
            <PreferredName>Pharmaceutical Preparations</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15750263">
    <Sentence section="abstract" number="1" text="To clarify the precise mechanisms involved in the reduced coronary flow reserve in hypertension, we compared the effects of the angiotensin II type 1 (AT1) receptor antagonist FK-739 with those of the angiotensin-converting enzyme (ACE) inhibitor enalapril for 6 weeks on the smooth muscle (SM) cell phenotype in intramyocardial arteries from male Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="176" text="FK-739">
            <CUI>C0252010</CUI>
            <PreferredName>FK 739</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Subject>
          <Object charOffset="128" text="angiotensin II type 1 (AT1) receptor antagonist">
            <CUI>C1449680</CUI>
            <PreferredName>Angiotensin II Type 1 Receptor Blockers</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="247" text="enalapril">
            <CUI>C0014025</CUI>
            <PreferredName>Enalapril</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="201" text="angiotensin-converting enzyme (ACE) inhibitor">
            <CUI>C0003015</CUI>
            <PreferredName>Angiotensin-Converting Enzyme Inhibitors</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COMPARED_WITH" indicatorType="VERB" charOffset="100" text="compared" />
          <Subject charOffset="176" text="FK-739">
            <CUI>C0252010</CUI>
            <PreferredName>FK 739</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Subject>
          <Object charOffset="247" text="enalapril">
            <CUI>C0014025</CUI>
            <PreferredName>Enalapril</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="337" text="from" />
          <Subject charOffset="329" text="arteries">
            <CUI>C0003842</CUI>
            <PreferredName>Arteries</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="348" text="Wistar-Kyoto rats">
            <CUI>C0034709</CUI>
            <PreferredName>Rats, Inbred WKY</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="337" text="from" />
          <Subject charOffset="329" text="arteries">
            <CUI>C0003842</CUI>
            <PreferredName>Arteries</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="376" text="spontaneously hypertensive rats">
            <CUI>C0034705</CUI>
            <PreferredName>Rats, Inbred SHR</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="309" text="in" />
          <Subject charOffset="329" text="arteries">
            <CUI>C0003842</CUI>
            <PreferredName>Arteries</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="276" text="smooth muscle (SM) cell">
            <CUI>C1135918</CUI>
            <PreferredName>Myocytes, Smooth Muscle</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="113" text="effects" />
          <Subject charOffset="247" text="enalapril">
            <CUI>C0014025</CUI>
            <PreferredName>Enalapril</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="276" text="smooth muscle (SM) cell">
            <CUI>C1135918</CUI>
            <PreferredName>Myocytes, Smooth Muscle</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="113" text="effects" />
          <Subject charOffset="176" text="FK-739">
            <CUI>C0252010</CUI>
            <PreferredName>FK 739</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Subject>
          <Object charOffset="276" text="smooth muscle (SM) cell">
            <CUI>C1135918</CUI>
            <PreferredName>Myocytes, Smooth Muscle</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15750284">
    <Sentence section="abstract" number="5" text="Thus, a physiological concentration of GH stimulated the differentiation of B-lymphoid precursors from bone marrow stem cells.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="COMPLEX" charOffset="42" text="stimulated the differentiation" />
          <Subject charOffset="39" text="GH">
            <CUI>C0037663</CUI>
            <PreferredName>Somatotropin</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Hormone</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="76" text="B-lymphoid precursors">
            <CUI>C1512631</CUI>
            <PreferredName>Immature B-Lymphocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="97" text="from" />
          <Subject charOffset="103" text="bone marrow stem cells">
            <CUI>C1511246</CUI>
            <PreferredName>Bone Marrow Stem Cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="76" text="B-lymphoid precursors">
            <CUI>C1512631</CUI>
            <PreferredName>Immature B-Lymphocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="Since mRNAs of both GH and GH receptor were present in stem cells and B-cell precursors in bone marrow, GH may modulate B-lymphoid precursors development in an autocrine or paracrine manner in bone marrows.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="51" text="in" />
          <Subject charOffset="55" text="stem cells">
            <CUI>C0038250</CUI>
            <PreferredName>Stem cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="6" text="mRNAs">
            <CUI>C0035696</CUI>
            <PreferredName>RNA, Messenger</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="11" text="of" />
          <Subject charOffset="6" text="mRNAs">
            <CUI>C0035696</CUI>
            <PreferredName>RNA, Messenger</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="20" text="GH">
            <CUI>C0037663</CUI>
            <PreferredName>Somatotropin</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Hormone</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="11" text="of" />
          <Subject charOffset="6" text="mRNAs">
            <CUI>C0035696</CUI>
            <PreferredName>RNA, Messenger</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="27" text="GH receptor">
            <CUI>C0034839</CUI>
            <PreferredName>Growth Hormone Receptor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="51" text="in" />
          <Subject charOffset="55" text="stem cells">
            <CUI>C0312738</CUI>
            <PreferredName>Pre-B Lymphocytes</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="6" text="mRNAs">
            <CUI>C0035696</CUI>
            <PreferredName>RNA, Messenger</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="87" text="in" />
          <Subject charOffset="70" text="B-cell precursors">
            <CUI>C0312738</CUI>
            <PreferredName>Pre-B Lymphocytes</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="91" text="bone marrow">
            <CUI>C0005953</CUI>
            <PreferredName>Bone Marrow</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="87" text="in" />
          <Subject charOffset="55" text="stem cells">
            <CUI>C0038250</CUI>
            <PreferredName>Stem cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="91" text="bone marrow">
            <CUI>C0005953</CUI>
            <PreferredName>Bone Marrow</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="111" text="modulate" />
          <Subject charOffset="104" text="GH">
            <CUI>C0037663</CUI>
            <PreferredName>Somatotropin</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Hormone</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="120" text="B-lymphoid precursors">
            <CUI>C1512631</CUI>
            <PreferredName>Immature B-Lymphocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="189" text="in" />
          <Subject charOffset="193" text="bone marrows">
            <CUI>C0005953</CUI>
            <PreferredName>Bone Marrow</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="120" text="B-lymphoid precursors">
            <CUI>C1512631</CUI>
            <PreferredName>Immature B-Lymphocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15763007">
    <Sentence section="title" number="1" text="Search and identification of spermatozoa and spermatids in the ejaculate of non-obstructive azoospermic patients.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="92" text="azoospermic">
            <CUI>C0004509</CUI>
            <PreferredName>Azoospermia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="104" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15765262">
    <Sentence section="title" number="1" text="Nicotine induces conditioned place preferences over a large range of doses in rats.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AUGMENTS" indicatorType="VERB" charOffset="9" text="induces" />
          <Subject charOffset="0" text="Nicotine">
            <CUI>C0028040</CUI>
            <PreferredName>Nicotine</PreferredName>
            <SemanticTypes>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Subject>
          <Object charOffset="17" text="conditioned place preferences">
            <CUI>C0815102</CUI>
            <PreferredName>place preference learning</PreferredName>
            <SemanticTypes>
              <SemanticType>Mental Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mental Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="74" text="in" />
          <Subject charOffset="17" text="conditioned place preferences">
            <CUI>C0815102</CUI>
            <PreferredName>place preference learning</PreferredName>
            <SemanticTypes>
              <SemanticType>Mental Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mental Process</RelationSemanticType>
          </Subject>
          <Object charOffset="78" text="rats">
            <CUI>C0034721</CUI>
            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="5" text="In subsequent conditioning trials, the compartment paired with nicotine was the initially preferred side for half of the rats, and the initially non-preferred side for the other half." />
  </MedlineCitation>
  <MedlineCitation pmid="15776283">
    <Sentence section="abstract" number="2" text="In this report, by using an ideal mouse model that expresses IFN-gamma locally in muscle, we demonstrate that sustained low-level expression of IFN-gamma promotes the development of several types of tumor including H22 hepatoma, MA782/5S mammary adenocarcinoma and B16 melanoma.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="78" text="in" />
          <Subject charOffset="82" text="muscle">
            <CUI>C0026845</CUI>
            <PreferredName>Muscle</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Subject>
          <Object charOffset="61" text="IFN-gamma">
            <CUI>C0021745</CUI>
            <PreferredName>Interferon Type II</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PREDISPOSES" indicatorType="VERB" charOffset="154" text="promotes" />
          <Subject charOffset="144" text="IFN-gamma">
            <CUI>C0021745</CUI>
            <PreferredName>Interferon Type II</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="199" text="tumor">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="205" text="including" />
          <Subject charOffset="219" text="hepatoma">
            <CUI>C0019204</CUI>
            <PreferredName>Primary carcinoma of the liver cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="199" text="tumor">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="205" text="including" />
          <Subject charOffset="238" text="mammary adenocarcinoma">
            <CUI>C0858252</CUI>
            <PreferredName>Breast adenocarcinoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="199" text="tumor">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="205" text="including" />
          <Subject charOffset="265" text="B16 melanoma">
            <CUI>C0004565</CUI>
            <PreferredName>Melanoma, B16</PreferredName>
            <SemanticTypes>
              <SemanticType>Experimental Model of Disease</SemanticType>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="199" text="tumor">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PREDISPOSES" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="144" text="IFN-gamma">
            <CUI>C0021745</CUI>
            <PreferredName>Interferon Type II</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="219" text="hepatoma">
            <CUI>C0019204</CUI>
            <PreferredName>Primary carcinoma of the liver cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PREDISPOSES" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="144" text="IFN-gamma">
            <CUI>C0021745</CUI>
            <PreferredName>Interferon Type II</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="238" text="mammary adenocarcinoma">
            <CUI>C0858252</CUI>
            <PreferredName>Breast adenocarcinoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PREDISPOSES" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="144" text="IFN-gamma">
            <CUI>C0021745</CUI>
            <PreferredName>Interferon Type II</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="265" text="B16 melanoma">
            <CUI>C0004565</CUI>
            <PreferredName>Melanoma, B16</PreferredName>
            <SemanticTypes>
              <SemanticType>Experimental Model of Disease</SemanticType>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15781005">
    <Sentence section="abstract" number="2" text="To assess the genetic and environmental determinants of BMD in southern Chinese women, we studied a community-based cohort of 531 pre- and postmenopausal southern Chinese women and assessed the influence of 12 candidate gene loci and lifestyle risk factors on spine and hip BMD.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="139" text="postmenopausal">
            <CUI>C0206159</CUI>
            <PreferredName>Postmenopause</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
          </Subject>
          <Object charOffset="171" text="women">
            <CUI>C0043210</CUI>
            <PreferredName>Woman</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="7" text="Using stepwise multiple linear regression analyses, body weight was the strongest predictor for BMD in premenopausal women (n = 262), which accounted for 15.9% of the variance at the spine, 20% at femoral neck, 17.1% at trochanter, 24.3% at total hip and 10.9% at the Ward's triangle.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="103" text="premenopausal">
            <CUI>C0206158</CUI>
            <PreferredName>Premenopause</PreferredName>
            <SemanticTypes>
              <SemanticType>Physiologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Physiologic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="117" text="women">
            <CUI>C0043210</CUI>
            <PreferredName>Woman</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="9" text="As for postmenopausal women (n = 269), body weight ( approximately 25% at various sites) and age (approximately 16% at femoral neck, trochanter, total hip and Ward's triangle sites) were the strongest predictors of BMD.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="7" text="postmenopausal">
            <CUI>C0206159</CUI>
            <PreferredName>Postmenopause</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
          </Subject>
          <Object charOffset="22" text="women">
            <CUI>C0043210</CUI>
            <PreferredName>Woman</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="10" text="Other significant predictors were age at menarche (4.4% at spine, 0.7% at femoral neck, 1.4% at trochanter, and 1.4% at Ward's triangle); weight bearing physical activity (2.1% at trochanter and 1% at total hip); calcium intake (1.1% at femoral neck, 0.9% at trochanter, and 1.7% at total hip) ; height (0.7% at trochanter); and ESR2 1082A/G genotype (0.8% at trochanter)." />
  </MedlineCitation>
  <MedlineCitation pmid="15790407">
    <Sentence section="abstract" number="1" text="Good quality clinical trials are essential to inform the best cystic fibrosis (CF) management and care, by determining and comparing the effectiveness of new and existing therapies and drug delivery systems." />
    <Sentence section="abstract" number="9" text="The interventions investigated were: antibiotics (4); home versus hospital administration of antibiotics (1); steroids (1); mucolytic therapies (6); exercise (3) and pancreatic enzymes (1).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="37" text="antibiotics">
            <CUI>C0003232</CUI>
            <PreferredName>Antibiotics</PreferredName>
            <SemanticTypes>
              <SemanticType>Antibiotic</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Antibiotic</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="interventions">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="110" text="steroids">
            <CUI>C0038317</CUI>
            <PreferredName>Steroids</PreferredName>
            <SemanticTypes>
              <SemanticType>Steroid</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Steroid</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="interventions">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="75" text="administration">
            <CUI>C1533734</CUI>
            <PreferredName>Administration procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="interventions">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="134" text="therapies">
            <CUI>C0087111</CUI>
            <PreferredName>Therapeutic procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="intervention">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="134" text="therapies">
            <CUI>C0087111</CUI>
            <PreferredName>Therapeutic procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="124" text="mucolytic">
            <CUI>C0770152</CUI>
            <PreferredName>MUCOLYTIC</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="149" text="exercise">
            <CUI>C0015259</CUI>
            <PreferredName>Exercise</PreferredName>
            <SemanticTypes>
              <SemanticType>Daily or Recreational Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Daily or Recreational Activity</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="interventions">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="93" text="antibiotics">
            <CUI>C0003232</CUI>
            <PreferredName>Antibiotics</PreferredName>
            <SemanticTypes>
              <SemanticType>Antibiotic</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Antibiotic</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="interventions">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="31" text="were" />
          <Subject charOffset="166" text="pancreatic enzymes">
            <CUI>C0920330</CUI>
            <PreferredName>Pancreatic enzyme</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="interventions">
            <CUI>C1273869</CUI>
            <PreferredName>Intervention regimes</PreferredName>
            <SemanticTypes>
              <SemanticType>Health Care Activity</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Health Care Activity</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15797093">
    <Sentence section="abstract" number="1" text="We report a case of primary cardiac epithelioid hemangioendothelioma arising from the right atrium of a 2-month-old infant.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="98" text="of" />
          <Subject charOffset="86" text="right atrium">
            <CUI>C1269890</CUI>
            <PreferredName>Entire right atrium</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="116" text="infant">
            <CUI>C0021270</CUI>
            <PreferredName>Infant</PreferredName>
            <SemanticTypes>
              <SemanticType>Age Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="76" text="from" />
          <Subject charOffset="86" text="right atrium">
            <CUI>C1269890</CUI>
            <PreferredName>Entire right atrium</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="epithelioid hemangioendothelioma">
            <CUI>C0206732</CUI>
            <PreferredName>Hemangioendothelioma, Epithelioid</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15802000">
    <Sentence section="abstract" number="15" text="The cost increase associated with treating nine patients with glargine rather than NPH is less than the cost of treating one hypoglycemia event.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="34" text="treating" />
          <Subject charOffset="62" text="glargine">
            <CUI>C0907402</CUI>
            <PreferredName>Insulin, Glargine, Human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Hormone</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="48" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="34" text="treating" />
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            <PreferredName>follow-up</PreferredName>
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              <SemanticType>Health Care Activity</SemanticType>
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  <MedlineCitation pmid="15913690">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Tertiary care hospital</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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            <CUI>C0023269</CUI>
            <PreferredName>leiomyosarcoma</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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            <PreferredName>leiomyosarcoma</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15919385">
    <Sentence section="abstract" number="8" text="The results on rheotactic behavior suggested a more complex regulatory mechanism, since TU but not T(4) treatment significantly affected rheotactic behavior." />
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  <MedlineCitation pmid="15919667">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Uridine Diphosphate Glucose</PreferredName>
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              <SemanticType>Carbohydrate</SemanticType>
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              <SemanticType>Biologically Active Substance</SemanticType>
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            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
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            <PreferredName>Proteoglycan</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
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            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Carbohydrate</SemanticType>
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            <PreferredName>Uridine Diphosphate Glucose</PreferredName>
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              <SemanticType>Biologically Active Substance</SemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="ADJ" charOffset="170" text="hypersensitive" />
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            <PreferredName>Phospholipase C</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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            <PreferredName>Cell Line</PreferredName>
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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              <SemanticType>Biologically Active Substance</SemanticType>
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              <SemanticType>Cell</SemanticType>
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      </Predications>
    </Sentence>
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              <SemanticType>Bacterium</SemanticType>
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              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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              <SemanticType>Carbohydrate</SemanticType>
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            <RelationSemanticType>Carbohydrate</RelationSemanticType>
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        </Predication>
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          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="66" text="sensitivity" />
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            <PreferredName>Phospholipase C</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="66" text="sensitivity" />
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              <SemanticType>Enzyme</SemanticType>
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <CUI>C0009063</CUI>
            <PreferredName>Clostridium perfringens</PreferredName>
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              <SemanticType>Bacterium</SemanticType>
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              <SemanticType>Bacterium</SemanticType>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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            <CUI>C0009063</CUI>
            <PreferredName>Clostridium perfringens</PreferredName>
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              <SemanticType>Bacterium</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
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        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="176" text="in" />
          <Subject charOffset="180" text="mice">
            <CUI>C0026809</CUI>
            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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  <MedlineCitation pmid="15919838">
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      <Predications>
        <Predication negated="false" inferred="false">
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            <PreferredName>Serum</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
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          <Object charOffset="68" text="VAP-1">
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            <PreferredName>AOC3 protein, human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="96" text="obese">
            <CUI>C0028754</CUI>
            <PreferredName>Obesity</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="102" text="subjects">
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              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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          <Object charOffset="102" text="subjects">
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  <MedlineCitation pmid="15925552">
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        <Predication negated="false" inferred="false">
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              <SemanticType>Body Substance</SemanticType>
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          <Object charOffset="107" text="human">
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    </Sentence>
    <Sentence section="abstract" number="3" text="Chromatographic separation was achieved on a C12 column using a mobile phase of acetonitrile/water with 0.2% formic acid (pH 2.4) (40/60, v/v)." />
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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  <MedlineCitation pmid="15969273">
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              <SemanticType>Bacterium</SemanticType>
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            <PreferredName>Antiphospholipid Syndrome</PreferredName>
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            <PreferredName>Polyamines</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="31" text="target vessel">
            <CUI>C0449618</CUI>
            <PreferredName>Target vessel</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Location or Region</SemanticType>
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            <RelationSemanticType>Body Location or Region</RelationSemanticType>
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            <PreferredName>CARDIAC EVENT</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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            <PreferredName>Renal dialysis status</PreferredName>
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              <SemanticType>Finding</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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            <PreferredName>Ejection fraction</PreferredName>
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            <PreferredName>Revascularization - action</PreferredName>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <PreferredName>Revascularization - action</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="15993989">
    <Sentence section="abstract" number="14" text="Sera of the mice immunized with i.m." />
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  <MedlineCitation pmid="15996060">
    <Sentence section="title" number="1" text="Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy.">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Rheumatoid Arthritis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="26" text="in" />
          <Subject charOffset="0" text="Sex hormone">
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            <PreferredName>Gonadal Steroid Hormones</PreferredName>
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              <SemanticType>Hormone</SemanticType>
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="2" text="In contrast, compared to controls, serum levels of estrogens are normal or elevated in women with RA.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="92" text="with" />
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            <PreferredName>Rheumatoid Arthritis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="98" text="RA">
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            <PreferredName>Woman</PreferredName>
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              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Estrogens</PreferredName>
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              <SemanticType>Hormone</SemanticType>
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            <PreferredName>Woman</PreferredName>
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              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="7" text="Serum levels of DHEAS and free testosterone were markedly lower at baseline in patients compared to controls, but this did not change during anti-TNF therapy.">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Dehydroepiandrosterone Sulfate</PreferredName>
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              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Hormone</SemanticType>
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    <Sentence section="abstract" number="10" text="CONCLUSION: Longterm therapy with anti-TNF did not change altered serum levels of typical sex hormones in patients with RA, although baseline values were largely different.">
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        </Predication>
        <Predication negated="true" inferred="false">
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            <PreferredName>Anti-tumor necrosis factor alpha drug</PreferredName>
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              <SemanticType>Hormone</SemanticType>
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            <RelationSemanticType>Hormone</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="11" text="In patients with RA, this indicates that alterations of sex hormones and altered activity of respective converting enzymes are imprinted for a long-lasting period over at least 12 weeks.">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Rheumatoid Arthritis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="15998787">
    <Sentence section="abstract" number="3" text="We show that disruption of the Nrf2 gene leads to severe allergen-driven airway inflammation and hyperresponsiveness in mice.">
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="ADJ" charOffset="66" text="driven" />
          <Subject charOffset="57" text="allergen">
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            <PreferredName>Allergens</PreferredName>
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              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Immunologic Factor</RelationSemanticType>
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              <SemanticType>Pathologic Function</SemanticType>
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            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
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            <CUI>C0458827</CUI>
            <PreferredName>Airway structure</PreferredName>
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              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
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            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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            <CUI>C0021368</CUI>
            <PreferredName>Inflammation</PreferredName>
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              <SemanticType>Pathologic Function</SemanticType>
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            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <CUI>C0021368</CUI>
            <PreferredName>Inflammation</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
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            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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            <PreferredName>Mus</PreferredName>
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              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="116" text="in" />
          <Subject charOffset="80" text="inflammation">
            <CUI>C0085129</CUI>
            <PreferredName>Bronchial Hyperreactivity</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="41" text="leads" />
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            <CUI>C1414905</CUI>
            <PreferredName>GABPA gene</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
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            <RelationSemanticType>Gene or Genome</RelationSemanticType>
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              <EntrezGeneTerm id="2551" name="GABPA" />
              <EntrezGeneTerm id="4780" name="NFE2L2" />
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              <SemanticType>Pathologic Function</SemanticType>
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            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="41" text="leads" />
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            <PreferredName>GABPA gene</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
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            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="2551" name="GABPA" />
              <EntrezGeneTerm id="4780" name="NFE2L2" />
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            <PreferredName>Bronchial Hyperreactivity</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="4" text="Enhanced asthmatic response as a result of ovalbumin sensitization and challenge in Nrf2-disrupted mice was associated with more pronounced mucus cell hyperplasia and infiltration of eosinophils into the lungs than seen in wild-type littermates.">
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        <Predication negated="false" inferred="false">
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            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Mus</PreferredName>
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              <SemanticType>Mammal</SemanticType>
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              <SemanticType>Mammal</SemanticType>
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        <Predication negated="false" inferred="false">
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        <Predication negated="false" inferred="false">
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="153" text="splenocytes">
            <CUI>C1519477</CUI>
            <PreferredName>Splenocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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            <PreferredName>Interleukin-4</PreferredName>
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              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="113" text="in" />
          <Subject charOffset="117" text="bronchoalveolar lavage fluid">
            <CUI>C0006279</CUI>
            <PreferredName>Bronchoalveolar Lavage Fluid</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
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            <PreferredName>Interleukin-13</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="113" text="in" />
          <Subject charOffset="117" text="bronchoalveolar lavage fluid">
            <CUI>C0006279</CUI>
            <PreferredName>Bronchoalveolar Lavage Fluid</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
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            <PreferredName>Interleukin-4</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
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            <CUI>C0021758</CUI>
            <PreferredName>Interleukin-4</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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            <PreferredName>cytokine</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="108" text="IL-13">
            <CUI>C0214743</CUI>
            <PreferredName>Interleukin-13</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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            <PreferredName>cytokine</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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  <MedlineCitation pmid="16000282">
    <Sentence section="abstract" number="10" text="The sensitivity of 18F-FDG PET for the identification of nodal metastases on a level-by-level basis was 22.1% higher than that of CT/MRI (74.7% vs. 52.6%, P &lt; 0.001), whereas the specificity of 18F-FDG PET was 1.5% lower than that of CT/MRI (93.0% vs. 94.5%, P = 0.345).">
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        <Predication negated="false" inferred="false">
          <Predicate type="DIAGNOSES" indicatorType="NOM" charOffset="39" text="identification" />
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            <CUI>C0872169</CUI>
            <PreferredName>fluorodeoxyglucose positron emission tomography</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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            <PreferredName>Neoplasm Metastasis</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DIAGNOSES" indicatorType="NOM" charOffset="39" text="identification" />
          <Subject charOffset="130" text="CT/MRI">
            <CUI>C0024485</CUI>
            <PreferredName>Magnetic Resonance Imaging</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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          <Object charOffset="63" text="metastases">
            <CUI>C0027627</CUI>
            <PreferredName>Neoplasm Metastasis</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16003269">
    <Sentence section="abstract" number="5" text="RESULTS: At 5 minutes after initiation of the pacing, giant pulmonary venous (PV) flow reversal (-76 cm/s) was observed in association with 1:1 ventriculoatrial conduction or complete atrioventricular dissociation." />
  </MedlineCitation>
  <MedlineCitation pmid="16012316">
    <Sentence section="abstract" number="8" text="RESULTS: The fraction of the range of ground-glass opacity and reticular opacity was greater in NSIP patients (32%, 12%) than in UIP patients (23%, 8%) (P &lt; 0.001).">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
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            <PreferredName>Nonspecific interstitial pneumonia</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="129" text="UIP">
            <CUI>C0085786</CUI>
            <PreferredName>Hamman-Rich syndrome</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="16015001">
    <Sentence section="abstract" number="5" text="Patients with higher serum phosphorus (P) (group A: P &gt; or = 7 mg/dl) were compared with those with lower serum P levels (group B: P &lt; 7 mg/dl).">
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="21" text="serum">
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            <PreferredName>Serum</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
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            <PreferredName>Phosphorus</PreferredName>
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              <SemanticType>Pharmacologic Substance</SemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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          <Object charOffset="27" text="phosphorus">
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            <PreferredName>Phosphorus</PreferredName>
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            <PreferredName>Patients</PreferredName>
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            <PreferredName>Phosphorus</PreferredName>
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    <Sentence section="abstract" number="14" text="CONCLUSION: Although iPTH and bAP are frequently in agreement, it seems important to separate parathyroid activity given by iPTH, from bone remodelling reflected by bAP, in the presence of either a higher aluminum exposition or a well-controlled phosphatemia.">
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        <Predication negated="false" inferred="false">
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              <SemanticType>Organ or Tissue Function</SemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Intact parathyrin</PreferredName>
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              <SemanticType>Hormone</SemanticType>
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        <Predication negated="false" inferred="false">
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="128" text="suicide">
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            <PreferredName>Suicide</PreferredName>
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              <SemanticType>Injury or Poisoning</SemanticType>
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            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
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              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="44" text="men">
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            <PreferredName>Male population group</PreferredName>
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              <SemanticType>Population Group</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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              <SemanticType>Age Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="52" text="women">
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              <SemanticType>Population Group</SemanticType>
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            <PreferredName>Adult</PreferredName>
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              <SemanticType>Age Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="106" text="relationship" />
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            <PreferredName>Acculturation</PreferredName>
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              <SemanticType>Social Behavior</SemanticType>
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              <SemanticType>Injury or Poisoning</SemanticType>
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      </Predications>
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  <MedlineCitation pmid="16024249">
    <Sentence section="abstract" number="1" text="Fasciolosis is an uncommon disease in this region, as are parasitic infections of the breast.">
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        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="12" text="is" />
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            <PreferredName>Fascioliasis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="27" text="disease">
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="78" text="of" />
          <Subject charOffset="86" text="breast">
            <CUI>C0006141</CUI>
            <PreferredName>Breast</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="58" text="parasitic infections">
            <CUI>C0747256</CUI>
            <PreferredName>Parasitic infection</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16025281">
    <Sentence section="abstract" number="6" text="BAFF-R expression was found only in B-cell lymphoma (44/80, positive cases/examined cases): B-lymphoblastic lymphoma 0/3, B-chronic lymphocytic leukemia/small lymphocytic lymphoma 4/4, mantle cell lymphoma 9/11, follicular lymphoma 10/14, diffuse large B-cell lymphoma (DLBCL) 11/25, marginal zone B-cell lymphoma 8/10, lymphoplasmacytic lymphoma 2/2, plasma cell myeloma 0/2, and Burkitt lymphoma 0/9, but not in T/NK cell lymphomas (0/19) or Hodgkin lymphoma (0/10).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="32" text="in" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="92" text="B-lymphoblastic lymphoma">
            <CUI>C2853919</CUI>
            <PreferredName>Lymphoblastic B-cell lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="122" text="B-chronic lymphocytic leukemia/small lymphocytic lymphoma">
            <CUI>C0861887</CUI>
            <PreferredName>B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="185" text="mantle cell lymphoma">
            <CUI>C0334634</CUI>
            <PreferredName>Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="212" text="follicular lymphoma">
            <CUI>C0024301</CUI>
            <PreferredName>Lymphoma, Follicular</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="239" text="diffuse large B-cell lymphoma">
            <CUI>C0079744</CUI>
            <PreferredName>Lymphoma, Large-Cell, Diffuse</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="284" text="marginal zone B-cell lymphoma">
            <CUI>C1367654</CUI>
            <PreferredName>Marginal zone B-cell lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="320" text="lymphoplasmacytic lymphoma">
            <CUI>C0024419</CUI>
            <PreferredName>Waldenstrom Macroglobulinemia</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="352" text="plasma cell myeloma">
            <CUI>C0026764</CUI>
            <PreferredName>Multiple Myeloma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="381" text="Burkitt lymphoma">
            <CUI>C0006413</CUI>
            <PreferredName>Burkitt Lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text=":" />
          <Subject charOffset="444" text="Hodgkin lymphoma">
            <CUI>C0019829</CUI>
            <PreferredName>Hodgkin Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="36" text="B-cell lymphoma">
            <CUI>C0079731</CUI>
            <PreferredName>B-Cell Lymphomas</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="92" text="B-lymphoblastic lymphoma">
            <CUI>C2853919</CUI>
            <PreferredName>Lymphoblastic B-cell lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="122" text="B-chronic lymphocytic leukemia/small lymphocytic lymphoma">
            <CUI>C0861887</CUI>
            <PreferredName>B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="185" text="mantle cell lymphoma">
            <CUI>C0334634</CUI>
            <PreferredName>Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="212" text="follicular lymphoma">
            <CUI>C0024301</CUI>
            <PreferredName>Lymphoma, Follicular</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="239" text="diffuse large B-cell lymphoma">
            <CUI>C0079744</CUI>
            <PreferredName>Lymphoma, Large-Cell, Diffuse</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="284" text="marginal zone B-cell lymphoma">
            <CUI>C1367654</CUI>
            <PreferredName>Marginal zone B-cell lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="320" text="lymphoplasmacytic lymphoma">
            <CUI>C0024419</CUI>
            <PreferredName>Waldenstrom Macroglobulinemia</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="352" text="plasma cell myeloma">
            <CUI>C0026764</CUI>
            <PreferredName>Multiple Myeloma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="381" text="Burkitt lymphoma">
            <CUI>C0006413</CUI>
            <PreferredName>Burkitt Lymphoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="true" inferred="true">
          <Predicate type="PART_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI>C1425064</CUI>
            <PreferredName>TNFRSF13C gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="444" text="Hodgkin lymphoma">
            <CUI>C0019829</CUI>
            <PreferredName>Hodgkin Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="7" text="BAFF-R was expressed in most low-grade B-cell neoplasms and a small number of DLBCL, suggesting that BAFF-R may play an important role in the proliferation of neoplastic lymphoid cells.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="VERB" charOffset="11" text="expressed" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI />
            <PreferredName />
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="10673" name="TNFSF13B" />
            </EntrezGene>
          </Subject>
          <Object charOffset="39" text="B-cell neoplasms">
            <CUI>C1332362</CUI>
            <PreferredName>B-cell neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="VERB" charOffset="11" text="expressed" />
          <Subject charOffset="0" text="BAFF-R">
            <CUI />
            <PreferredName />
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="10673" name="TNFSF13B" />
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          </Subject>
          <Object charOffset="78" text="DLBCL">
            <CUI>C0079744</CUI>
            <PreferredName>Lymphoma, Large-Cell, Diffuse</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="130" text="role" />
          <Subject charOffset="101" text="BAFF-R">
            <CUI />
            <PreferredName />
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="10673" name="TNFSF13B" />
            </EntrezGene>
          </Subject>
          <Object charOffset="142" text="proliferation">
            <CUI>C0596290</CUI>
            <PreferredName>Cell Proliferation</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PREP" charOffset="155" text="of" />
          <Subject charOffset="142" text="proliferation">
            <CUI>C0596290</CUI>
            <PreferredName>Cell Proliferation</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Subject>
          <Object charOffset="170" text="lymphoid cells">
            <CUI>C0086574</CUI>
            <PreferredName>Lymphoid Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="170" text="lymphoid cells">
            <CUI>C0086574</CUI>
            <PreferredName>Lymphoid Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="159" text="neoplastic">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16030174">
    <Sentence section="abstract" number="5" text="PARTICIPANTS: We studied women with regular cycles (n = 36) and women with PCOS (n = 8).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="69" text="with" />
          <Subject charOffset="75" text="PCOS">
            <CUI>C0032460</CUI>
            <PreferredName>Polycystic Ovary Syndrome</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="64" text="women">
            <CUI>C0043210</CUI>
            <PreferredName>Woman</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="30" text="with" />
          <Subject charOffset="44" text="cycles">
            <CUI>C0025329</CUI>
            <PreferredName>Menstrual cycle</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
          </Subject>
          <Object charOffset="25" text="women">
            <CUI>C0043210</CUI>
            <PreferredName>Woman</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
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    </Sentence>
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              <SemanticType>Body Substance</SemanticType>
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        <Predication negated="false" inferred="false">
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  <MedlineCitation pmid="16040903">
    <Sentence section="abstract" number="2" text="MATERIALS AND METHODS: The study was approved by the institutional review board and, where appropriate, was compliant with the Health Insurance Portability and Accountability Act." />
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            <PreferredName>Peritoneal lavage</PreferredName>
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            <PreferredName>valganciclovir</PreferredName>
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  <MedlineCitation pmid="16097204">
    <Sentence section="abstract" number="6" text="Only 89% of the patients reported complete compliance with the prescription." />
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            <PreferredName>Veratridine</PreferredName>
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            <PreferredName>neuropeptide Y</PreferredName>
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        <Predication negated="false" inferred="false">
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            <PreferredName>T-Lymphocyte</PreferredName>
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              <SemanticType>Cell</SemanticType>
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        <Predication negated="false" inferred="false">
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        <Predication negated="false" inferred="false">
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        <Predication inferred="true" negated="false">
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              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PREDISPOSES" indicatorType="NOM" charOffset="49" text="predictor" />
          <Subject charOffset="16" text="homocysteine">
            <CUI>C0019879</CUI>
            <PreferredName>Homocystine</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="62" text="steatohepatitis">
            <CUI>C2711227</CUI>
            <PreferredName>Steatohepatitis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="1" text="BACKGROUND: Although steatosis is common in patients with severe hyperhomocysteinemia due to deficiency of cystathionine beta-synthase, there are no satisfactory data on homocysteine concentrations in patients with non-alcoholic fatty liver disease.">
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        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="215" text="non-alcoholic fatty liver">
            <CUI>C0400966</CUI>
            <PreferredName>Non-alcoholic fatty liver</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
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            <CUI>C0012634</CUI>
            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="209" text="with" />
          <Subject charOffset="241" text="disease">
            <CUI>C0012634</CUI>
            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="201" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PROCESS_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="215" text="non-alcoholic fatty liver">
            <CUI>C0400966</CUI>
            <PreferredName>Non-alcoholic fatty liver</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="201" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="40" text="in" />
          <Subject charOffset="21" text="steatosis">
            <CUI>C0152254</CUI>
            <PreferredName>Fatty degeneration</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="44" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="52" text="with" />
          <Subject charOffset="65" text="hyperhomocysteinemia">
            <CUI>C0598608</CUI>
            <PreferredName>Hyperhomocysteinemia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="44" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="COMPLEX" charOffset="86" text="due to" />
          <Subject charOffset="107" text="cystathionine beta-synthase">
            <CUI>C0010641</CUI>
            <PreferredName>Cystathionine beta-Synthase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="65" text="hyperhomocysteinemia">
            <CUI>C0598608</CUI>
            <PreferredName>Hyperhomocysteinemia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="197" text="in" />
          <Subject charOffset="170" text="homocysteine">
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            <PreferredName>Homocystine</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="201" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="4" text="Homocysteine levels were measured by high-performance liquid chromatography." />
    <Sentence section="abstract" number="5" text="Insulin, folate, vitamin B(12) and lipoprotein levels were also determined in all groups." />
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      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="95" text="non-alcoholic fatty liver">
            <CUI>C0400966</CUI>
            <PreferredName>Non-alcoholic fatty liver</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
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            <CUI>C0012634</CUI>
            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="77" text="in" />
          <Subject charOffset="81" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Subject>
          <Object charOffset="24" text="homocysteine">
            <CUI>C0019879</CUI>
            <PreferredName>Homocystine</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="89" text="with" />
          <Subject charOffset="121" text="disease">
            <CUI>C0012634</CUI>
            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="81" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="PROCESS_OF" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="95" text="non-alcoholic fatty liver">
            <CUI>C0400966</CUI>
            <PreferredName>Non-alcoholic fatty liver</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="81" text="patients">
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="16109053">
    <Sentence section="title" number="1" text="An introduction to the basic principles of health economics for those involved in the development and delivery of headache care." />
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    <Sentence section="abstract" number="2" text="In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation.">
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="67" text="induce" />
          <Subject charOffset="46" text="interleukin 1">
            <CUI>C0021755</CUI>
            <PreferredName>Interleukin-1</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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          <Object charOffset="74" text="lung inflammation">
            <CUI>C0032285</CUI>
            <PreferredName>Pneumonia</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="67" text="induce" />
          <Subject charOffset="32" text="endotoxin">
            <CUI>C0014264</CUI>
            <PreferredName>Endotoxins</PreferredName>
            <SemanticTypes>
              <SemanticType>Carbohydrate</SemanticType>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
              <SemanticType>Lipid</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Carbohydrate</RelationSemanticType>
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          <Object charOffset="74" text="lung inflammation">
            <CUI>C0032285</CUI>
            <PreferredName>Pneumonia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="0" text="In" />
          <Subject charOffset="74" text="lung inflammation">
            <CUI>C0032285</CUI>
            <PreferredName>Pneumonia</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Domestic Sheep</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="0" text="In" />
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            <CUI>C1254042</CUI>
            <PreferredName>Anatomical maturation</PreferredName>
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              <SemanticType>Physiologic Function</SemanticType>
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            <RelationSemanticType>Physiologic Function</RelationSemanticType>
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          <Object charOffset="11" text="lambs">
            <CUI>C1123019</CUI>
            <PreferredName>Domestic Sheep</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="109" text="maturation">
            <CUI>C1254042</CUI>
            <PreferredName>Anatomical maturation</PreferredName>
            <SemanticTypes>
              <SemanticType>Physiologic Function</SemanticType>
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            <RelationSemanticType>Physiologic Function</RelationSemanticType>
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            <CUI>C0024109</CUI>
            <PreferredName>Lung</PreferredName>
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              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="PRECEDES" indicatorType="PART" charOffset="92" text="followed" />
          <Subject charOffset="74" text="lung inflammation">
            <CUI>C0032285</CUI>
            <PreferredName>Pneumonia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="109" text="maturation">
            <CUI>C1254042</CUI>
            <PreferredName>Anatomical maturation</PreferredName>
            <SemanticTypes>
              <SemanticType>Physiologic Function</SemanticType>
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            <RelationSemanticType>Physiologic Function</RelationSemanticType>
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    <Sentence section="abstract" number="4" text="METHODS: Lung inflammation was induced by intraamniotic injection of endotoxin or IL-1.">
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="31" text="induced" />
          <Subject charOffset="56" text="injection">
            <CUI>C1533685</CUI>
            <PreferredName>Injection procedure</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <PreferredName>Pneumonia</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="PREP" charOffset="65" text="of" />
          <Subject charOffset="56" text="injection">
            <CUI>C1533685</CUI>
            <PreferredName>Injection procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <PreferredName>Endotoxins</PreferredName>
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              <SemanticType>Carbohydrate</SemanticType>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
              <SemanticType>Lipid</SemanticType>
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            <RelationSemanticType>Carbohydrate</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Injection procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <PreferredName>Interleukin-1</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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    <Sentence section="abstract" number="1" text="Spam emails are considered as a serious privacy-related violation, besides being a costly, unsolicited communication." />
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    <Sentence section="abstract" number="2" text="MATERIAL AND METHODS: Twenty-one channel EEG of 21 patients with Down syndrome and 21 normal children, with ages ranging from 1 to 8 years, were submitted to quantitative analysis EEG of discharge-free epochs.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="59" text="with" />
          <Subject charOffset="65" text="Down syndrome">
            <CUI>C0013080</CUI>
            <PreferredName>Down Syndrome</PreferredName>
            <SemanticTypes>
              <SemanticType>Congenital Abnormality</SemanticType>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Congenital Abnormality</RelationSemanticType>
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="PREP" charOffset="44" text="of" />
          <Subject charOffset="41" text="EEG">
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            <PreferredName>Electroencephalogram</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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          <Object charOffset="51" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="PREP" charOffset="44" text="of" />
          <Subject charOffset="41" text="EEG">
            <CUI>C1527380</CUI>
            <PreferredName>Electroencephalogram</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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          <Object charOffset="93" text="children">
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            <PreferredName>Child</PreferredName>
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              <SemanticType>Age Group</SemanticType>
              <SemanticType>Intellectual Product</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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  <MedlineCitation pmid="16121636">
    <Sentence section="abstract" number="3" text="The various variables analyzed were number of megakaryocytes and micromegakaryocytes, area, perimeter and diameter of the megakaryocytic elements." />
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        <Predication negated="false" inferred="false">
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            <PreferredName>Detection</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="79" text="detection">
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            <PreferredName>Detection</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="4" text="In the case of pregnancies, detection of fetal DNA in maternal plasma is a useful tool for detecting and monitoring certain fetal diseases and pregnancy-associated complications.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="63" text="plasma">
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            <PreferredName>Plasma</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <PreferredName>Mothers</PreferredName>
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              <SemanticType>Family Group</SemanticType>
              <SemanticType>Human</SemanticType>
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="63" text="plasma">
            <CUI>C0032105</CUI>
            <PreferredName>Plasma</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="47" text="DNA">
            <CUI>C0012854</CUI>
            <PreferredName>DNA</PreferredName>
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              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DIAGNOSES" indicatorType="VERB" charOffset="91" text="detecting" />
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            <CUI>C1511790</CUI>
            <PreferredName>Detection</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
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            <CUI>C0015929</CUI>
            <PreferredName>Fetal Diseases</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DIAGNOSES" indicatorType="VERB" charOffset="91" text="detecting" />
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            <CUI>C1511790</CUI>
            <PreferredName>Detection</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
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            <CUI>C0032962</CUI>
            <PreferredName>Pregnancy Complications</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16138263">
    <Sentence section="abstract" number="5" text="Male Wistar rats were treated with L-thyroxin (25 microg/100 g, sc, od) for fourteen days, while normal rats served as controls.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="22" text="treated" />
          <Subject charOffset="35" text="L-thyroxin">
            <CUI>C0040165</CUI>
            <PreferredName>Thyroxine</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Hormone</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="5" text="Wistar rats">
            <CUI>C0034716</CUI>
            <PreferredName>Rats, Wistar</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16141404">
    <Sentence section="abstract" number="6" text="As shown by real-time quantitative reverse-transcription polymerase chain reaction (RT-PCR), EPC stimulation by SFLLRN significantly enhanced the mRNA expression of SDF-1 and its receptor CXCR-4.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AUGMENTS" indicatorType="NOM" charOffset="97" text="stimulation" />
          <Subject charOffset="112" text="SFLLRN">
            <CUI>C0219419</CUI>
            <PreferredName>thrombin receptor peptide (42-47)</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="93" text="EPC">
            <CUI>C0038250</CUI>
            <PreferredName>Stem cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="8" text="PAR-1 stimulation by SFLLRN also increased the formation of capillary-like structures by EPC in Matrigel, and this effect was abrogated by anti-CXCR-4, anti-SDF-1, and MEK inhibitor pretreatment.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="STIMULATES" indicatorType="NOM" charOffset="6" text="stimulation" />
          <Subject charOffset="21" text="SFLLRN">
            <CUI>C0219419</CUI>
            <PreferredName>thrombin receptor peptide (42-47)</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="PAR-1">
            <CUI>C1366449</CUI>
            <PreferredName>F2R gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="2149" name="F2R" />
            </EntrezGene>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="9" text="CONCLUSIONS: Human EPCs express functional PAR-1.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PRODUCES" indicatorType="VERB" charOffset="24" text="express" />
          <Subject charOffset="19" text="EPCs">
            <CUI>C0038250</CUI>
            <PreferredName>Stem cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="43" text="PAR-1">
            <CUI>C0668084</CUI>
            <PreferredName>Receptor, PAR-1</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16144778">
    <Sentence section="abstract" number="8" text="Results indicate that the cardio-respiratory depression evoked by anandamide administered via the peripheral circulation requires intact supranodose vagi.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="56" text="evoked" />
          <Subject charOffset="66" text="anandamide">
            <CUI>C0211726</CUI>
            <PreferredName>anandamide</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Eicosanoid</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="33" text="respiratory depression">
            <CUI>C0235063</CUI>
            <PreferredName>Respiratory Depression</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="26" text="cardio">
            <CUI>C0018787</CUI>
            <PreferredName>Heart</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="33" text="respiratory depression">
            <CUI>C0235063</CUI>
            <PreferredName>Respiratory Depression</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16146326">
    <Sentence section="abstract" number="1" text="BACKGROUND AND PURPOSE: To describe the timings and ranges of linear displacements of the pelvis and feet occurring in a healthy older population when stepping up onto a step, and to describe variations noted in a small sample of subjects with hemiplegia.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="238" text="with" />
          <Subject charOffset="244" text="hemiplegia">
            <CUI>C0018991</CUI>
            <PreferredName>Hemiplegia</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="230" text="subjects">
            <CUI>C2349001</CUI>
            <PreferredName>Human Study Subject</PreferredName>
            <SemanticTypes>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16149149">
    <Sentence section="title" number="1" text="Effect of Gui Zhi decoction on enteric mucosal immune in mice with collagen-induced arthritis.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="61" text="with" />
          <Subject charOffset="67" text="collagen-induced arthritis">
            <CUI>C0971858</CUI>
            <PreferredName>Arthritis, Collagen-Induced</PreferredName>
            <SemanticTypes>
              <SemanticType>Experimental Model of Disease</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Experimental Model of Disease</RelationSemanticType>
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          <Object charOffset="57" text="mice">
            <CUI>C0026809</CUI>
            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16154523">
    <Sentence section="title" number="1" text="Simultaneous enantioselective determination of amphetamine and congeners in hair specimens by negative chemical ionization gas chromatography-mass spectrometry.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="72" text="in" />
          <Subject charOffset="76" text="hair specimens">
            <CUI>C0444095</CUI>
            <PreferredName>Hair Specimen</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="47" text="amphetamine">
            <CUI>C0002658</CUI>
            <PreferredName>Amphetamine</PreferredName>
            <SemanticTypes>
              <SemanticType>Neuroreactive Substance or Biogenic Amine</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="72" text="in" />
          <Subject charOffset="76" text="hair specimens">
            <CUI>C0444095</CUI>
            <PreferredName>Hair Specimen</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="63" text="congeners">
            <CUI>C0678518</CUI>
            <PreferredName>congener</PreferredName>
            <SemanticTypes>
              <SemanticType>Chemical Viewed Structurally</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Chemical Viewed Structurally</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="Intra- and inter-assay precision and respective accuracy were acceptable." />
    <Sentence section="abstract" number="7" text="The enantiomeric ratios (R versus S) of AM, MA, MDA, MDMA and MDEA were determined in hair from suspected amphetamine abusers.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="82" text="in" />
          <Subject charOffset="86" text="hair">
            <CUI>C0018494</CUI>
            <PreferredName>hair</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="62" text="MDEA">
            <CUI>C0946224</CUI>
            <PreferredName>METHYLENEDIOXYETHYLAMPHETAMINE</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="82" text="in" />
          <Subject charOffset="86" text="hair">
            <CUI>C0018494</CUI>
            <PreferredName>hair</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="53" text="MDMA">
            <CUI>C0115471</CUI>
            <PreferredName>Ecstasy - drug</PreferredName>
            <SemanticTypes>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="82" text="in" />
          <Subject charOffset="86" text="hair">
            <CUI>C0018494</CUI>
            <PreferredName>hair</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="40" text="AM">
            <CUI>C0002658</CUI>
            <PreferredName>Amphetamine</PreferredName>
            <SemanticTypes>
              <SemanticType>Neuroreactive Substance or Biogenic Amine</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="82" text="in" />
          <Subject charOffset="86" text="hair">
            <CUI>C0018494</CUI>
            <PreferredName>hair</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="44" text="MA">
            <CUI>C0025611</CUI>
            <PreferredName>Methamphetamine</PreferredName>
            <SemanticTypes>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="82" text="in" />
          <Subject charOffset="86" text="hair">
            <CUI>C0018494</CUI>
            <PreferredName>hair</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="48" text="MDA">
            <CUI>C0000379</CUI>
            <PreferredName>3,4-Methylenedioxyamphetamine</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="106" text="amphetamine">
            <CUI>C0002658</CUI>
            <PreferredName>Amphetamine</PreferredName>
            <SemanticTypes>
              <SemanticType>Neuroreactive Substance or Biogenic Amine</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organic Chemical</RelationSemanticType>
          </Subject>
          <Object charOffset="118" text="abusers">
            <CUI>C0338666</CUI>
            <PreferredName>Drug abuser</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="90" text="from" />
          <Subject charOffset="86" text="hair">
            <CUI>C0018494</CUI>
            <PreferredName>hair</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="118" text="abusers">
            <CUI>C0338666</CUI>
            <PreferredName>Drug abuser</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16160007">
    <Sentence section="title" number="1" text="Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="0" text="Modulation" />
          <Subject charOffset="113" text="missense mutation">
            <CUI>C0599155</CUI>
            <PreferredName>Mutation, Missense</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="14" text="ADAMTS13">
            <CUI>C1413036</CUI>
            <PreferredName>ADAMTS13 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="11093" name="ADAMTS13" />
            </EntrezGene>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="0" text="Modulation" />
          <Subject charOffset="93" text="polymorphisms">
            <CUI>C0032529</CUI>
            <PreferredName>Polymorphism, Genetic</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="14" text="ADAMTS13">
            <CUI>C1413036</CUI>
            <PreferredName>ADAMTS13 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="11093" name="ADAMTS13" />
            </EntrezGene>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="93" text="polymorphisms">
            <CUI>C0032529</CUI>
            <PreferredName>Polymorphism, Genetic</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="82" text="amino acid">
            <CUI>C0002520</CUI>
            <PreferredName>Amino Acids</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="1" text="Sequence analysis of the ADAMTS13 locus of 2 patients with hereditary thrombotic thrombocytopenic purpura (TTP) revealed the homozygous presence of 4 single nucleotide polymorphisms (SNPs) (R7W, Q448E, P618A, A732V) and a rare missense mutation (R1336W).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="53" text="with" />
          <Subject charOffset="70" text="thrombotic thrombocytopenic purpura">
            <CUI>C0034155</CUI>
            <PreferredName>Purpura, Thrombotic Thrombocytopenic</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="45" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="39" text="of" />
          <Subject charOffset="25" text="ADAMTS13">
            <CUI>C1413036</CUI>
            <PreferredName>ADAMTS13 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="11093" name="ADAMTS13" />
            </EntrezGene>
          </Subject>
          <Object charOffset="45" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16160855">
    <Sentence section="abstract" number="2" text="Denervation was performed by cutting the sciatic nerve.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="METHOD_OF" indicatorType="PREP" charOffset="25" text="by" />
          <Subject charOffset="29" text="cutting">
            <CUI>C0152060</CUI>
            <PreferredName>Transection (procedure)</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="Denervation">
            <CUI>C0011307</CUI>
            <PreferredName>Denervation</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16167756">
    <Sentence section="abstract" number="8" text="CONCLUSIONS: Manifestations of SS disease differ in malarial areas and it is questionable whether interventions developed in non-malarial areas apply.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="31" text="SS">
            <CUI>C0086981</CUI>
            <PreferredName>Sicca Syndrome</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="34" text="disease">
            <CUI>C0012634</CUI>
            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16167981">
    <Sentence section="abstract" number="2" text="Grey shows an autosomal dominant inheritance and the locus has previously been mapped to horse chromosome 25 (ECA25), around the TXN gene." />
  </MedlineCitation>
  <MedlineCitation pmid="16172203">
    <Sentence section="abstract" number="1" text="BACKGROUND: The relative effectiveness of second-generation (atypical) antipsychotic drugs as compared with that of older agents has been incompletely addressed, though newer agents are currently used far more commonly.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="COMPARED_WITH" indicatorType="PART" charOffset="94" text="compared" />
          <Subject charOffset="71" text="antipsychotic drugs">
            <CUI>C0040615</CUI>
            <PreferredName>Antipsychotic Agents</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="122" text="agents">
            <CUI>C0450442</CUI>
            <PreferredName>Agent</PreferredName>
            <SemanticTypes>
              <SemanticType>Chemical Viewed Functionally</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Chemical Viewed Functionally</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="8" text="The times to discontinuation because of intolerable side effects were similar among the groups, but the rates differed (P=0.04); olanzapine was associated with more discontinuation for weight gain or metabolic effects, and perphenazine was associated with more discontinuation for extrapyramidal effects." />
  </MedlineCitation>
  <MedlineCitation pmid="16172797">
    <Sentence section="title" number="1" text="High grade primary breast lymphoma: is it a different clinical entity?" />
    <Sentence section="abstract" number="1" text="Primary lymphoma of the breast (PBL) is a rare neoplasm, its outcome remains unclear compared to other lymphomas.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="37" text="is" />
          <Subject charOffset="8" text="lymphoma of the breast">
            <CUI>C0349669</CUI>
            <PreferredName>Malignant lymphoma of breast</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="47" text="neoplasm">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16173158">
    <Sentence section="abstract" number="1" text="This issue contains peer-reviewed papers from a workshop on Closed Ecological Systems: Earth and Space Applications at the 35th COSPAR General Assembly in Paris, France, convened in July 2004." />
  </MedlineCitation>
  <MedlineCitation pmid="16176149">
    <Sentence section="abstract" number="9" text="In conclusion, the AM extract produced a very weak effect on the prevention of bone loss induced by OVX and Ca deficiency in rats, but was similar to the results observed with alendronate.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="PART" charOffset="89" text="induced" />
          <Subject charOffset="108" text="Ca deficiency">
            <CUI>C0392519</CUI>
            <PreferredName>Calcium deficiency</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="79" text="bone loss">
            <CUI>C0599877</CUI>
            <PreferredName>loss; bone</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="PART" charOffset="89" text="induced" />
          <Subject charOffset="100" text="OVX">
            <CUI>C0029936</CUI>
            <PreferredName>Ovariectomy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="79" text="bone loss">
            <CUI>C0599877</CUI>
            <PreferredName>loss; bone</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="121" text="in" />
          <Subject charOffset="108" text="Ca deficiency">
            <CUI>C0392519</CUI>
            <PreferredName>Calcium deficiency</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="125" text="rats">
            <CUI>C0034721</CUI>
            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="PREP" charOffset="121" text="in" />
          <Subject charOffset="100" text="OVX">
            <CUI>C0029936</CUI>
            <PreferredName>Ovariectomy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="125" text="rats">
            <CUI>C0034721</CUI>
            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PREVENTS" indicatorType="NOM" charOffset="65" text="prevention" />
          <Subject charOffset="22" text="extract">
            <CUI>C2828366</CUI>
            <PreferredName>Extract (substance)</PreferredName>
            <SemanticTypes>
              <SemanticType>Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="79" text="bone loss">
            <CUI>C0599877</CUI>
            <PreferredName>loss; bone</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16177843">
    <Sentence section="title" number="1" text="Prevalence and diagnosis of schizophrenia based on register, case record and interview data in an isolated Finnish birth cohort born 1940-1969.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="OCCURS_IN" indicatorType="PREP" charOffset="91" text="in" />
          <Subject charOffset="28" text="schizophrenia">
            <CUI>C0036341</CUI>
            <PreferredName>Schizophrenia</PreferredName>
            <SemanticTypes>
              <SemanticType>Mental or Behavioral Dysfunction</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mental or Behavioral Dysfunction</RelationSemanticType>
          </Subject>
          <Object charOffset="121" text="cohort">
            <CUI>C0599755</CUI>
            <PreferredName>cohort</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="5" text="The corresponding birth cohort of 14,817 persons and 12,368 alive in 1998 was identified from the National Population Register." />
    <Sentence section="abstract" number="6" text="We validated 69% of the register diagnosis by making DSM-IV consensus diagnoses, and interviewed 131 (55%) of the 237 patients with SCID-I and SCID-II." />
    <Sentence section="abstract" number="7" text="RESULTS: The register-based lifetime prevalence was 1.5% for schizophrenia and 1.9% for schizophrenia spectrum psychotic disorders: in birth cohorts born 1945 to 1959, the latter prevalence was especially high (2.4%).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="88" text="schizophrenia">
            <CUI>C0036341</CUI>
            <PreferredName>Schizophrenia</PreferredName>
            <SemanticTypes>
              <SemanticType>Mental or Behavioral Dysfunction</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mental or Behavioral Dysfunction</RelationSemanticType>
          </Subject>
          <Object charOffset="111" text="psychotic disorders">
            <CUI>C0033975</CUI>
            <PreferredName>Psychotic Disorders</PreferredName>
            <SemanticTypes>
              <SemanticType>Mental or Behavioral Dysfunction</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mental or Behavioral Dysfunction</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="OCCURS_IN" indicatorType="NOM" charOffset="179" text="prevalence" />
          <Subject charOffset="111" text="psychotic disorders">
            <CUI>C0033975</CUI>
            <PreferredName>Psychotic Disorders</PreferredName>
            <SemanticTypes>
              <SemanticType>Mental or Behavioral Dysfunction</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mental or Behavioral Dysfunction</RelationSemanticType>
          </Subject>
          <Object charOffset="141" text="cohort">
            <CUI>C0599755</CUI>
            <PreferredName>cohort</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16181881">
    <Sentence section="abstract" number="1" text="BACKGROUND: Off-pump, closed, beating heart, minimally-invasive surgery in patients with lone atrial fibrillation (AF) must be effective to become the preferred alternative to catheter ablation.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="83" text="with" />
          <Subject charOffset="89" text="lone atrial fibrillation">
            <CUI>C0340489</CUI>
            <PreferredName>Lone atrial fibrillation</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="75" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="71" text="in" />
          <Subject charOffset="64" text="surgery">
            <CUI>C0543467</CUI>
            <PreferredName>Operative Surgical Procedures</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="75" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="64" text="surgery">
            <CUI>C0543467</CUI>
            <PreferredName>Operative Surgical Procedures</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="89" text="lone atrial fibrillation">
            <CUI>C0340489</CUI>
            <PreferredName>Lone atrial fibrillation</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16182253">
    <Sentence section="abstract" number="1" text="Several nuclear and cytoplasmic proteins in metazoans are modified by O-linked N-acetylglucosamine (O-GlcNAc).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="40" text="in" />
          <Subject charOffset="20" text="cytoplasmic protein">
            <CUI>C1333198</CUI>
            <PreferredName>Cytoplasmic Protein</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="44" text="metazoans">
            <CUI>C0320223</CUI>
            <PreferredName>Metazoa</PreferredName>
            <SemanticTypes>
              <SemanticType>Invertebrate</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Invertebrate</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="40" text="in" />
          <Subject charOffset="8" text="nuclear">
            <CUI>C0949374</CUI>
            <PreferredName>Nuclear Protein</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="44" text="metazoans">
            <CUI>C0320223</CUI>
            <PreferredName>Metazoa</PreferredName>
            <SemanticTypes>
              <SemanticType>Invertebrate</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Invertebrate</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="Mutations in the SCA10 gene cause progressive cerebellar ataxias and seizures.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="28" text="cause" />
          <Subject charOffset="0" text="Mutations">
            <CUI>C0026882</CUI>
            <PreferredName>Mutation</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="34" text="progressive cerebellar ataxias">
            <CUI>C0393525</CUI>
            <PreferredName>Progressive cerebellar ataxia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="28" text="cause" />
          <Subject charOffset="0" text="Mutations">
            <CUI>C0026882</CUI>
            <PreferredName>Mutation</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="69" text="seizures">
            <CUI>C0036572</CUI>
            <PreferredName>Seizures</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PREP" charOffset="9" text="in" />
          <Subject charOffset="0" text="Mutations">
            <CUI>C0026882</CUI>
            <PreferredName>Mutation</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="17" text="SCA10 gene">
            <CUI>C1419829</CUI>
            <PreferredName>SCA10 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="25814" name="ATXN10" />
            </EntrezGene>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="CAUSES" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="17" text="SCA10 gene">
            <CUI>C1419829</CUI>
            <PreferredName>SCA10 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="25814" name="ATXN10" />
            </EntrezGene>
          </Subject>
          <Object charOffset="34" text="progressive cerebellar ataxias">
            <CUI>C0393525</CUI>
            <PreferredName>Progressive cerebellar ataxia</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="CAUSES" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="17" text="SCA10 gene">
            <CUI>C1419829</CUI>
            <PreferredName>SCA10 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="25814" name="ATXN10" />
            </EntrezGene>
          </Subject>
          <Object charOffset="69" text="seizures">
            <CUI>C0036572</CUI>
            <PreferredName>Seizures</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="7" text="We demonstrate that SCA10 interacts with OGT in vivo and is modified by O-linked glycosylation in MIN6 cells, suggesting a novel role for the Ataxin-10 protein in pancreatic beta cells.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="VERB" charOffset="26" text="interacts" />
          <Subject charOffset="20" text="SCA10">
            <CUI>C1419829</CUI>
            <PreferredName>SCA10 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="25814" name="ATXN10" />
            </EntrezGene>
          </Subject>
          <Object charOffset="41" text="OGT">
            <CUI>C1121142</CUI>
            <PreferredName>O-GlcNAc transferase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="94" text="in" />
          <Subject charOffset="103" text="cells">
            <CUI>C0007634</CUI>
            <PreferredName>Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="72" text="O-linked glycosylation">
            <CUI>C1621325</CUI>
            <PreferredName>protein amino acid O-linked glycosylation</PreferredName>
            <SemanticTypes>
              <SemanticType>Molecular Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Molecular Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="60" text="modified" />
          <Subject charOffset="72" text="O-linked glycosylation">
            <CUI>C1621325</CUI>
            <PreferredName>protein amino acid O-linked glycosylation</PreferredName>
            <SemanticTypes>
              <SemanticType>Molecular Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Molecular Function</RelationSemanticType>
          </Subject>
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            <CUI>C1419829</CUI>
            <PreferredName>SCA10 gene</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="25814" name="ATXN10" />
            </EntrezGene>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="129" text="role" />
          <Subject charOffset="142" text="Ataxin-10 protein">
            <CUI>C1609855</CUI>
            <PreferredName>ATXN10 protein, human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
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            <EntrezGene>
              <EntrezGeneTerm id="25814" name="ATXN10" />
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          </Subject>
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            <CUI>C0030281</CUI>
            <PreferredName>Structure of beta Cell of islet</PreferredName>
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16185180">
    <Sentence section="abstract" number="8" text="Patients with severe MDRPA infections should be treated with combination therapy, consisting of an antipseudomonal beta-lactam with an aminoglycoside or fluoroquinolone rather than aminoglycoside and fluoroquinolone combinations, to provide adequate therapy and improve patient outcomes.">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Combined Modality Therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="8" text="with" />
          <Subject charOffset="21" text="MDRPA">
            <CUI>C0854135</CUI>
            <PreferredName>Pseudomonas aeruginosa infection NOS</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="0" text="Patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="61" text="combination therapy">
            <CUI>C0009429</CUI>
            <PreferredName>Combined Modality Therapy</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="21" text="MDRPA">
            <CUI>C0854135</CUI>
            <PreferredName>Pseudomonas aeruginosa infection NOS</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="VERB" charOffset="82" text="consisting" />
          <Subject charOffset="61" text="combination therapy">
            <CUI>C0009429</CUI>
            <PreferredName>Combined Modality Therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <PreferredName>beta-Lactams</PreferredName>
            <SemanticTypes>
              <SemanticType>Antibiotic</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Antibiotic</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="VERB" charOffset="82" text="consisting" />
          <Subject charOffset="61" text="combination therapy">
            <CUI>C0009429</CUI>
            <PreferredName>Combined Modality Therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <CUI>C0002556</CUI>
            <PreferredName>Aminoglycosides</PreferredName>
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              <SemanticType>Carbohydrate</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="VERB" charOffset="82" text="consisting" />
          <Subject charOffset="61" text="combination therapy">
            <CUI>C0009429</CUI>
            <PreferredName>Combined Modality Therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <PreferredName>Fluoroquinolones</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="9" text="Synergy has been observed when resistant antipseudomonal drugs were combined in vitro against MDRPA with successful clinical application reported in two centers." />
  </MedlineCitation>
  <MedlineCitation pmid="16185321">
    <Sentence section="abstract" number="1" text="Killer cell immunoglobulin-like receptors (KIRs) belong to a diverse family of natural killer (NK) cell receptors recognizing human leukocyte antigen (HLA) class I molecules.">
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        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="49" text="belong to a diverse family of" />
          <Subject charOffset="0" text="Killer cell immunoglobulin-like receptors">
            <CUI>C0665952</CUI>
            <PreferredName>killer inhibitory receptor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="104" text="receptors">
            <CUI>C0597357</CUI>
            <PreferredName>receptor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="VERB" charOffset="114" text="recognizing" />
          <Subject charOffset="104" text="receptors">
            <CUI>C0597357</CUI>
            <PreferredName>receptor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="126" text="human leukocyte antigen">
            <CUI>C0019721</CUI>
            <PreferredName>HLA Antigens</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="INTERACTS_WITH" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="0" text="Killer cell immunoglobulin-like receptors">
            <CUI>C0665952</CUI>
            <PreferredName>killer inhibitory receptor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="126" text="human leukocyte antigen">
            <CUI>C0019721</CUI>
            <PreferredName>HLA Antigens</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16194167">
    <Sentence section="title" number="1" text="Can transthoracic echocardiography with subcostal view predict abdominal aortic atherosclerosis?">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="DIAGNOSES" indicatorType="VERB" charOffset="55" text="predict" />
          <Subject charOffset="4" text="transthoracic echocardiography">
            <CUI>C0430462</CUI>
            <PreferredName>Transthoracic echocardiography</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="63" text="abdominal aortic atherosclerosis">
            <CUI>C0398356</CUI>
            <PreferredName>Abdominal aortic atherosclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="2" text="During transthoracic echocardiography (TTE), subcostal views may suggest abdominal (ABD) aortic (AO) ATH, but this diagnosis may be inaccurate due to suboptimal images, which may in part relate to use of nonlinear probes." />
    <Sentence section="abstract" number="10" text="TTE correlated with TEE grading with an r = 0.42 (P = 0.0001) for patients (n = 75) with adequate TTE and r = 0.32 (P = 0.001) for all patients (n = 100), including those with suboptimal TTE images.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="PREP" charOffset="83" text="with" />
          <Subject charOffset="98" text="TTE">
            <CUI>C0430462</CUI>
            <PreferredName>Transthoracic echocardiography</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="66" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="PREP" charOffset="170" text="with" />
          <Subject charOffset="187" text="TTE">
            <CUI>C0430462</CUI>
            <PreferredName>Transthoracic echocardiography</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="135" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
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            <PreferredName>Transthoracic echocardiography</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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          <Object charOffset="191" text="images">
            <CUI>C0025086</CUI>
            <PreferredName>Medical Imaging</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16194666">
    <Sentence section="abstract" number="6" text="These findings suggest that, in this study area, arsenic concentrations in most wells remain stable over time and a limited number of measurements per well can be used to predict arsenic exposures over a period of many years." />
  </MedlineCitation>
  <MedlineCitation pmid="16197815">
    <Sentence section="abstract" number="4" text="METHODS: Nine patients with ALS were randomly assigned to receive either a high dose (3 microg/kg of body weight) or low dose (0.5 microg/kg of body weight) of IGF-1 every 2 weeks for 40 weeks.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="22" text="with" />
          <Subject charOffset="28" text="ALS">
            <CUI>C0002736</CUI>
            <PreferredName>Amyotrophic Lateral Sclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="14" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="VERB" charOffset="58" text="receive" />
          <Subject charOffset="160" text="IGF-1">
            <CUI>C0021665</CUI>
            <PreferredName>Insulin-Like Growth Factor I</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="14" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="RESULTS: The high-dose treatment slowed a decline of motor functions of the ALS patients in total Norris and limb Norris scales, but not in bulbar Norris or vital capacity.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="76" text="ALS">
            <CUI>C0002736</CUI>
            <PreferredName>Amyotrophic Lateral Sclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="80" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="COMPLEX" charOffset="33" text="slowed a decline" />
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            <PreferredName>Therapeutic procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="53" text="motor functions">
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            <PreferredName>Motor function</PreferredName>
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              <SemanticType>Functional Concept</SemanticType>
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            <RelationSemanticType>Functional Concept</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16204062">
    <Sentence section="abstract" number="3" text="We recently showed that the atypical PKC (aPKC) isozyme PKCiota is overexpressed in human non-small cell lung cancer (NSCLC) cells and that PKCiota plays a critical role in the transformed growth of the human lung adenocarcinoma A549 cell line in vitro and tumorigenicity in vivo.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="56" text="PKCiota">
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            <PreferredName>protein kinase C iota</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="5584" name="PRKCI" />
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          </Subject>
          <Object charOffset="48" text="isozyme">
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            <PreferredName>Isoenzymes</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="165" text="role" />
          <Subject charOffset="140" text="PKCiota">
            <CUI>C0667917</CUI>
            <PreferredName>protein kinase C iota</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="5584" name="PRKCI" />
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          </Subject>
          <Object charOffset="257" text="tumorigenicity">
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            <PreferredName>Tumorigenicity</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
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            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="165" text="role" />
          <Subject charOffset="140" text="PKCiota">
            <CUI>C0667917</CUI>
            <PreferredName>protein kinase C iota</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="5584" name="PRKCI" />
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          </Subject>
          <Object charOffset="203" text="human lung adenocarcinoma A549 cell line">
            <CUI>C0682523</CUI>
            <PreferredName>Human Cell Line</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="203" text="human lung adenocarcinoma A549 cell line">
            <CUI>C0682523</CUI>
            <PreferredName>Human Cell Line</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="209" text="lung adenocarcinoma">
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            <PreferredName>Adenocarcinoma of lung</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="125" text="cells">
            <CUI>C0007634</CUI>
            <PreferredName>Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="90" text="non-small cell lung cancer (NSCLC)">
            <CUI>C0007131</CUI>
            <PreferredName>Carcinoma, Non-Small-Cell Lung</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="125" text="cells">
            <CUI>C0007634</CUI>
            <PreferredName>Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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          <Object charOffset="84" text="human">
            <CUI>C0086418</CUI>
            <PreferredName>Homo sapiens</PreferredName>
            <SemanticTypes>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        <Predication inferred="true" negated="false">
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              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="4" text="Here we provide compelling evidence that PKCiota is an oncogene in NSCLC based on the following criteria: (a) aPKCiota is overexpressed in the vast majority of primary NSCLC tumors; (b) tumor PKCiota expression levels predict poor survival in patients with NSCLC; (c) the PKCiota gene is frequently amplified in established NSCLC cell lines and primary NSCLC tumors; (d) gene amplification drives PKCiota expression in NSCLC cell lines and primary NSCLC tumors; and (e) disruption of PKCiota signaling with a dominant negative PKCiota allele blocks the transformed growth of human NSCLC cells harboring PKCiota gene amplification.">
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            <PreferredName>Hepatitis A</PreferredName>
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  <MedlineCitation pmid="16260962">
    <Sentence section="abstract" number="3" text="METHODS: After venous blood sampling, subjects (16 CFS patients) performed a maximal exercise stress test on a bicycle ergometer with continuous monitoring of cardiorespiratory variables.">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Chronic Fatigue Syndrome</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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              <SemanticType>Human</SemanticType>
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          <Subject charOffset="85" text="exercise stress test">
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            <PreferredName>Exercise stress test</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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          <Subject charOffset="85" text="exercise stress test">
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            <PreferredName>Exercise stress test</PreferredName>
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              <SemanticType>Diagnostic Procedure</SemanticType>
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            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
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          <Object charOffset="111" text="bicycle ergometer">
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            <PreferredName>Bicycle ergometer</PreferredName>
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              <SemanticType>Medical Device</SemanticType>
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            <RelationSemanticType>Medical Device</RelationSemanticType>
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    <Sentence section="abstract" number="6" text="CONCLUSION: These data provide evidence for an association between intracellular immune deregulation and exercise performance in patients with CFS.">
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            <PreferredName>Chronic Fatigue Syndrome</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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  <MedlineCitation pmid="16261927">
    <Sentence section="abstract" number="2" text="Whether the change in behaviour is related to opioid-induced sedation or to insufficient pain relief remains to be investigated.">
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="ADJ" charOffset="53" text="induced" />
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            <PreferredName>Opioids</PreferredName>
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              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <PreferredName>Sedation</PreferredName>
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              <SemanticType>Sign or Symptom</SemanticType>
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        <Predication negated="false" inferred="false">
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            <CUI>C0600097</CUI>
            <PreferredName>Sedation</PreferredName>
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              <SemanticType>Sign or Symptom</SemanticType>
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            <PreferredName>Behavioral change</PreferredName>
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              <SemanticType>Individual Behavior</SemanticType>
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            <RelationSemanticType>Individual Behavior</RelationSemanticType>
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      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16266740">
    <Sentence section="title" number="1" text="Cadmium and lead contamination in japonica rice grains and its variation among the different locations in southeast China.">
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="MOD_HEAD" charOffset="" text="" />
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            <PreferredName>Cadmium</PreferredName>
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              <SemanticType>Element, Ion, or Isotope</SemanticType>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
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            <RelationSemanticType>Hazardous or Poisonous Substance</RelationSemanticType>
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            <CUI>C2364322</CUI>
            <PreferredName>Contamination (environmental process)</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Natural Phenomenon or Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="12" text="lead">
            <CUI>C0023175</CUI>
            <PreferredName>Lead</PreferredName>
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              <SemanticType>Element, Ion, or Isotope</SemanticType>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="30" text="in" />
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            <CUI>C0086369</CUI>
            <PreferredName>Grains</PreferredName>
            <SemanticTypes>
              <SemanticType>Plant</SemanticType>
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            <RelationSemanticType>Plant</RelationSemanticType>
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            <PreferredName>Contamination (environmental process)</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
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            <CUI>C1140671</CUI>
            <PreferredName>Oryza sativa</PreferredName>
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              <SemanticType>Plant</SemanticType>
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            <RelationSemanticType>Plant</RelationSemanticType>
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            <PreferredName>Grains</PreferredName>
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              <SemanticType>Plant</SemanticType>
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      </Predications>
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    <Sentence section="abstract" number="1" text="On the basis of a large-scale survey with 269 sampling sites and a field experiment with 12 cultivars grown at 3 ecologically different locations, Cadmium (Cd) and lead (Pb) contamination in milled rice grains and its variation among different locations were investigated in the area of southeast China.">
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="46" text="sampling site">
            <CUI>C0449705</CUI>
            <PreferredName>Site of sampling</PreferredName>
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              <SemanticType>Spatial Concept</SemanticType>
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            <RelationSemanticType>Spatial Concept</RelationSemanticType>
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            <PreferredName>Surveys</PreferredName>
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              <SemanticType>Research Activity</SemanticType>
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        <Predication negated="false" inferred="false">
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            <CUI>C0006632</CUI>
            <PreferredName>Cadmium</PreferredName>
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              <SemanticType>Element, Ion, or Isotope</SemanticType>
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            <PreferredName>Contamination (environmental process)</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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            <RelationSemanticType>Natural Phenomenon or Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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            <CUI>C0023175</CUI>
            <PreferredName>Lead</PreferredName>
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              <SemanticType>Element, Ion, or Isotope</SemanticType>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
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            <RelationSemanticType>Hazardous or Poisonous Substance</RelationSemanticType>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="203" text="grains">
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            <PreferredName>Grains</PreferredName>
            <SemanticTypes>
              <SemanticType>Plant</SemanticType>
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            <RelationSemanticType>Plant</RelationSemanticType>
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            <PreferredName>Contamination (environmental process)</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="198" text="rice">
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            <PreferredName>Oryza sativa</PreferredName>
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              <SemanticType>Plant</SemanticType>
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            <RelationSemanticType>Plant</RelationSemanticType>
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          <Object charOffset="203" text="grains">
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            <PreferredName>Grains</PreferredName>
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              <SemanticType>Plant</SemanticType>
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            <RelationSemanticType>Plant</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="16272203">
    <Sentence section="abstract" number="8" text="Regional wall motion assessed by circumferential shortening velocity suggested enhanced circumferential fiber contractility in the Ren-2 rats (P = 0.02), but tissue Doppler imaging, used to assess longitudinal function, was not different between groups.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="123" text="in" />
          <Subject charOffset="110" text="contractility">
            <CUI>C1258017</CUI>
            <PreferredName>Heart Contractility</PreferredName>
            <SemanticTypes>
              <SemanticType>Organ or Tissue Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organ or Tissue Function</RelationSemanticType>
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          <Object charOffset="137" text="rats">
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            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16272824">
    <Sentence section="abstract" number="7" text="Secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and IL-6 in supernatants from HMC-1 cells was measured by a sandwich enzyme-linked immunosorbent assay.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="99" text="from" />
          <Subject charOffset="87" text="supernatants">
            <CUI>C1550101</CUI>
            <PreferredName>Supernatant</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="111" text="cells">
            <CUI>C0007634</CUI>
            <PreferredName>Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="83" text="in" />
          <Subject charOffset="87" text="supernatants">
            <CUI>C1550101</CUI>
            <PreferredName>Supernatant</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
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          <Object charOffset="13" text="tumor necrosis factor-alpha">
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            <PreferredName>Tumor Necrosis Factor-alpha</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="83" text="in" />
          <Subject charOffset="87" text="supernatants">
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            <PreferredName>Supernatant</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="54" text="interleukin-8">
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            <PreferredName>Interleukin-8</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="83" text="in" />
          <Subject charOffset="87" text="supernatants">
            <CUI>C1550101</CUI>
            <PreferredName>Supernatant</PreferredName>
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              <SemanticType>Body Substance</SemanticType>
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            <RelationSemanticType>Body Substance</RelationSemanticType>
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          <Object charOffset="79" text="IL-6">
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            <PreferredName>Interleukin-6</PreferredName>
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              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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    </Sentence>
    <Sentence section="abstract" number="12" text="Significantly reduced levels (p &lt; 0.05) of TNF-alpha, IL-8 and IL-6 were observed in the human mast cell line with SPS and SPS components.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="81" text="in" />
          <Subject charOffset="89" text="human mast cell line">
            <CUI>C0682523</CUI>
            <PreferredName>Human Cell Line</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
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          <Object charOffset="63" text="IL-6">
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            <PreferredName>Interleukin-6</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="81" text="in" />
          <Subject charOffset="89" text="human mast cell line">
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            <PreferredName>Human Cell Line</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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          <Object charOffset="43" text="TNF-alpha">
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            <PreferredName>Tumor Necrosis Factor-alpha</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="81" text="in" />
          <Subject charOffset="89" text="human mast cell line">
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            <PreferredName>Human Cell Line</PreferredName>
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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          <Object charOffset="54" text="IL-8">
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              <SemanticType>Immunologic Factor</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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          <Subject charOffset="89" text="human mast cell line">
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            <PreferredName>Human Cell Line</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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          <Object charOffset="115" text="SPS">
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            <PreferredName>sopoongsan</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Organic Chemical</RelationSemanticType>
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    <Sentence section="abstract" number="14" text="CONCLUSIONS: These findings suggest that SPS has an inhibitory effect on atopic allergic reaction and this might be useful for the clinical application to treat allergic diseases such as AD.">
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        <Predication negated="false" inferred="false">
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            <CUI>C1701972</CUI>
            <PreferredName>sopoongsan</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
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            <PreferredName>sopoongsan</PreferredName>
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    <Sentence section="abstract" number="1" text="The present study was designed to evaluate the effects of long-term use of aqueous extract of gutkha (a form of smokeless tobacco) on the antioxidant defense status and histopathological changes in liver, lung, and kidney of male Wistar rats.">
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  <MedlineCitation pmid="16281706">
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        <Predication negated="false" inferred="false">
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              <SemanticType>Genetic Function</SemanticType>
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            <RelationSemanticType>Genetic Function</RelationSemanticType>
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              <SemanticType>Cell Function</SemanticType>
              <SemanticType>Molecular Function</SemanticType>
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            <RelationSemanticType>Cell Function</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="12" text="In conclusion, the frequency of mutations in the cAMP signal transduction pathway was found to be lower than expected in the Turkish population most likely because of the use of SSCP as a screening method and sequencing only a part of TSHR exon 10.">
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              <SemanticType>Genetic Function</SemanticType>
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              <SemanticType>Biologically Active Substance</SemanticType>
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  <MedlineCitation pmid="16284524">
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          <Object charOffset="22" text="individuals">
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              <SemanticType>Group</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
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            <PreferredName>NFKB1 gene</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="4790" name="NFKB1" />
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            <CUI>C0162638</CUI>
            <PreferredName>Apoptosis</PreferredName>
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              <SemanticType>Cell Function</SemanticType>
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            <RelationSemanticType>Cell Function</RelationSemanticType>
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        <Predication inferred="true" negated="false">
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            <CUI>C0376515</CUI>
            <PreferredName>BCL2 gene</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
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          <Object charOffset="94" text="apoptosis">
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            <PreferredName>Apoptosis</PreferredName>
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              <SemanticType>Cell Function</SemanticType>
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            <RelationSemanticType>Cell Function</RelationSemanticType>
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      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16290001">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="51" text="with" />
          <Subject charOffset="82" text="cervical adenocarcinoma">
            <CUI>C0279672</CUI>
            <PreferredName>Cervical Adenocarcinoma</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PART" charOffset="106" text="treated" />
          <Subject charOffset="119" text="radical hysterectomy">
            <CUI>C0677962</CUI>
            <PreferredName>Radical hysterectomy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="82" text="cervical adenocarcinoma">
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            <PreferredName>Cervical Adenocarcinoma</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PART" charOffset="106" text="treated" />
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            <CUI>C0193883</CUI>
            <PreferredName>Pelvic lymphadenectomy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="82" text="cervical adenocarcinoma">
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            <PreferredName>Cervical Adenocarcinoma</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="3" text="Of the 163 patients, 116 had preoperative serum CA125 levels, and 14 had pelvic lymph node metastasis.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="73" text="pelvic">
            <CUI>C0030797</CUI>
            <PreferredName>Pelvis</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Location or Region</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Location or Region</RelationSemanticType>
          </Subject>
          <Object charOffset="80" text="lymph node metastasis">
            <CUI>C0686619</CUI>
            <PreferredName>Secondary malignant neoplasm of lymph node</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="VERB" charOffset="69" text="had" />
          <Subject charOffset="80" text="lymph node metastasis">
            <CUI>C0686619</CUI>
            <PreferredName>Secondary malignant neoplasm of lymph node</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="11" text="patients">
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16291723">
    <Sentence section="abstract" number="2" text="Coincident with actomyosin ring constriction, primary and secondary septa are deposited and then the primary septum is degraded to release daughter cells from one another." />
    <Sentence section="abstract" number="9" text="Our data suggest that the three closely related fission yeast Rho-GEF molecules perform two distinct essential functions.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="62" text="Rho-GEF">
            <CUI>C0606872</CUI>
            <PreferredName>rho guanine nucleotide exchange factor p115</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="9181" name="ARHGEF2" />
              <EntrezGeneTerm id="56731" name="SLC2A4RG" />
            </EntrezGene>
          </Subject>
          <Object charOffset="48" text="fission yeast">
            <CUI>C0178453</CUI>
            <PreferredName>Schizosaccharomyces pombe</PreferredName>
            <SemanticTypes>
              <SemanticType>Fungus</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fungus</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16291815">
    <Sentence section="abstract" number="1" text="ATP-activated currents were studied in Leydig cells of mice with the patch-clamp technique.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="51" text="of" />
          <Subject charOffset="39" text="Leydig cells">
            <CUI>C0023602</CUI>
            <PreferredName>Structure of interstitial cell of Leydig</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="55" text="mice">
            <CUI>C0026809</CUI>
            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16296031">
    <Sentence section="abstract" number="17" text="This can be concluded from their precipitation with the sera against the bovine serum proteins in the immunoelectrophoresis test.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="80" text="serum proteins">
            <CUI>C0036825</CUI>
            <PreferredName>Serum Proteins</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="73" text="bovine">
            <CUI>C1140701</CUI>
            <PreferredName>Bos taurus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16303761">
    <Sentence section="abstract" number="2" text="The interaction of HGF with c-met, a receptor tyrosine kinase expressed by many cells, is important in cell growth, migration, and formation of endothelial and epithelial tubes.">
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        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="NOM" charOffset="4" text="interaction" />
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            <CUI>C0072453</CUI>
            <PreferredName>Proto-Oncogene Protein c-met</PreferredName>
            <SemanticTypes>
              <SemanticType>Receptor</SemanticType>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="HGF">
            <CUI>C0062534</CUI>
            <PreferredName>Hepatocyte Growth Factor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRODUCES" indicatorType="PART" charOffset="62" text="expressed" />
          <Subject charOffset="80" text="cells">
            <CUI>C0007634</CUI>
            <PreferredName>Cells</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="37" text="receptor tyrosine kinase">
            <CUI>C0206364</CUI>
            <PreferredName>Receptor Protein-Tyrosine Kinases</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="33" text="," />
          <Subject charOffset="28" text="c-met">
            <CUI>C0072453</CUI>
            <PreferredName>Proto-Oncogene Protein c-met</PreferredName>
            <SemanticTypes>
              <SemanticType>Receptor</SemanticType>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="37" text="receptor tyrosine kinase">
            <CUI>C0206364</CUI>
            <PreferredName>Receptor Protein-Tyrosine Kinases</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="Here we show that chymases, which are chymotryptic peptidases secreted by mast cells, hydrolyze HGF, thereby abolishing scatter factor activity while generating an NK4-like antagonist of HGF scatter factor activity.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="34" text="are" />
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            <CUI>C0055673</CUI>
            <PreferredName>Chymase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="51" text="peptidases">
            <CUI>C0030940</CUI>
            <PreferredName>Peptide Hydrolases</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRODUCES" indicatorType="PART" charOffset="62" text="secreted" />
          <Subject charOffset="74" text="mast cell">
            <CUI>C0024880</CUI>
            <PreferredName>mast cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="18" text="chymases">
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            <PreferredName>Chymase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="INTERACTS_WITH" indicatorType="VERB" charOffset="86" text="hydrolyze" />
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            <CUI>C0055673</CUI>
            <PreferredName>Chymase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="96" text="HGF">
            <CUI>C0062534</CUI>
            <PreferredName>Hepatocyte Growth Factor</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
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            <RelationSemanticType>Gene or Genome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="INHIBITS" indicatorType="VERB" charOffset="109" text="abolishing" />
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            <CUI>C0055673</CUI>
            <PreferredName>Chymase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="120" text="scatter factor">
            <CUI>C0062534</CUI>
            <PreferredName>Hepatocyte Growth Factor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRODUCES" indicatorType="VERB" charOffset="150" text="generating" />
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            <CUI>C0055673</CUI>
            <PreferredName>Chymase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="173" text="antagonist">
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            <PreferredName>antagonists</PreferredName>
            <SemanticTypes>
              <SemanticType>Chemical Viewed Functionally</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Chemical Viewed Functionally</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DISRUPTS" indicatorType="NOM" charOffset="173" text="antagonist" />
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            <CUI>C1537404</CUI>
            <PreferredName>IL32 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="9235" name="IL32" />
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          </Subject>
          <Object charOffset="191" text="scatter factor activity">
            <CUI>C1149472</CUI>
            <PreferredName>growth factor activity</PreferredName>
            <SemanticTypes>
              <SemanticType>Molecular Function</SemanticType>
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            <RelationSemanticType>Molecular Function</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="10" text="Mast cell/neutrophil cathepsin G and neutrophil elastase generate similar fragments of HGF by cleaving near the chymase site.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
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            <CUI>C0054868</CUI>
            <PreferredName>Cathepsin G</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="1511" name="CTSG" />
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          </Subject>
          <Object charOffset="10" text="neutrophil">
            <CUI>C0027950</CUI>
            <PreferredName>neutrophil</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="21" text="cathepsin G">
            <CUI>C0054868</CUI>
            <PreferredName>Cathepsin G</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="1511" name="CTSG" />
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          </Subject>
          <Object charOffset="0" text="Mast cell">
            <CUI>C0024880</CUI>
            <PreferredName>mast cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRODUCES" indicatorType="VERB" charOffset="57" text="generate" />
          <Subject charOffset="37" text="neutrophil elastase">
            <CUI>C0064833</CUI>
            <PreferredName>Leukocyte Elastase</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="87" text="HGF">
            <CUI>C0062534</CUI>
            <PreferredName>Hepatocyte Growth Factor</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRODUCES" indicatorType="VERB" charOffset="57" text="generate" />
          <Subject charOffset="37" text="neutrophil elastase">
            <CUI>C0054868</CUI>
            <PreferredName>Cathepsin G</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="1511" name="CTSG" />
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          </Subject>
          <Object charOffset="87" text="HGF">
            <CUI>C0062534</CUI>
            <PreferredName>Hepatocyte Growth Factor</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16304222">
    <Sentence section="title" number="1" text="Low-dose anticoagulation in Chinese patients with mechanical heart valves.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="24" text="in" />
          <Subject charOffset="9" text="anticoagulation">
            <CUI>C0003281</CUI>
            <PreferredName>anticoagulation</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Patient or Disabled Group</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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          <Subject charOffset="36" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
          </Subject>
          <Object charOffset="50" text="mechanical heart valves">
            <CUI>C0493527</CUI>
            <PreferredName>HEART-VALVE, MECHANICAL</PreferredName>
            <SemanticTypes>
              <SemanticType>Medical Device</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Medical Device</RelationSemanticType>
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  <MedlineCitation pmid="16310382">
    <Sentence section="abstract" number="1" text="Cystitis, urethritis and pyelonephritis in cattle most commonly result from ascending urinary tract infection with Corynebacterium renale, Corynebacterium cystidis, Corynebacterium pilosum or Escherichia coli.">
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        <Predication negated="false" inferred="false">
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            <CUI>C0010692</CUI>
            <PreferredName>Cystitis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="43" text="cattle">
            <CUI>C0007452</CUI>
            <PreferredName>Cattle</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="39" text="in" />
          <Subject charOffset="10" text="urethritis">
            <CUI>C0041976</CUI>
            <PreferredName>Urethritis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <CUI>C0007452</CUI>
            <PreferredName>Cattle</PreferredName>
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              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="39" text="in" />
          <Subject charOffset="25" text="pyelonephritis">
            <CUI>C0034186</CUI>
            <PreferredName>Pyelonephritis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="43" text="cattle">
            <CUI>C0007452</CUI>
            <PreferredName>Cattle</PreferredName>
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              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="64" text="result" />
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            <CUI>C0042029</CUI>
            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <CUI>C0010692</CUI>
            <PreferredName>Cystitis</PreferredName>
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="64" text="result" />
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            <CUI>C0042029</CUI>
            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="10" text="urethritis">
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            <PreferredName>Urethritis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="64" text="result" />
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            <CUI>C0042029</CUI>
            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <PreferredName>Pyelonephritis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="PREP" charOffset="109" text="with" />
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            <CUI>C0315176</CUI>
            <PreferredName>Corynebacterium renale</PreferredName>
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              <SemanticType>Bacterium</SemanticType>
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          <Object charOffset="86" text="urinary tract infection">
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            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="PREP" charOffset="109" text="with" />
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            <PreferredName>Corynebacterium pilosum</PreferredName>
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              <SemanticType>Bacterium</SemanticType>
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            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="PREP" charOffset="109" text="with" />
          <Subject charOffset="192" text="Escherichia coli">
            <CUI>C0014834</CUI>
            <PreferredName>Escherichia coli</PreferredName>
            <SemanticTypes>
              <SemanticType>Bacterium</SemanticType>
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            <RelationSemanticType>Bacterium</RelationSemanticType>
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            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="2" text="We describe the clinical, bacteriological, clinical-pathological and epidemiological findings in a dairy cattle herd with urinary tract infection (UTI).">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="116" text="with" />
          <Subject charOffset="122" text="urinary tract infection">
            <CUI>C0042029</CUI>
            <PreferredName>Urinary tract infection</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="99" text="dairy cattle">
            <CUI>C0175925</CUI>
            <PreferredName>Dairy cattle</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="93" text="in" />
          <Subject charOffset="85" text="findings">
            <CUI>C0037088</CUI>
            <PreferredName>Signs and Symptoms</PreferredName>
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              <SemanticType>Sign or Symptom</SemanticType>
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            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
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          <Object charOffset="99" text="dairy cattle">
            <CUI>C0175925</CUI>
            <PreferredName>Dairy cattle</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16311763">
    <Sentence section="abstract" number="4" text="Transcript levels for factors involved in mitochondrial biogenesis (PGC-1alpha, Tfam), mitochondrial function (COX-1, COX-4), control of contractile phenotype (MyHC I, IIa, IIx) as well as mechanical stress marker (IGF-I) were quantified using an reverse-transcriptase polymerase chain reaction approach.">
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        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PART" charOffset="30" text="involved" />
          <Subject charOffset="68" text="PGC-1alpha">
            <CUI>C1418779</CUI>
            <PreferredName>PPARGC1A gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="5225" name="PGC" />
            </EntrezGene>
          </Subject>
          <Object charOffset="56" text="biogenesis">
            <CUI>C0005495</CUI>
            <PreferredName>Biogenesis</PreferredName>
            <SemanticTypes>
              <SemanticType>Natural Phenomenon or Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Natural Phenomenon or Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PART" charOffset="30" text="involved" />
          <Subject charOffset="80" text="Tfam">
            <CUI>C1420696</CUI>
            <PreferredName>TFAM gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="7019" name="TFAM" />
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          <Object charOffset="56" text="biogenesis">
            <CUI>C0005495</CUI>
            <PreferredName>Biogenesis</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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            <RelationSemanticType>Natural Phenomenon or Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="42" text="mitochondrial">
            <CUI>C0026237</CUI>
            <PreferredName>Mitochondria</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
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          <Object charOffset="56" text="biogenesis">
            <CUI>C0005495</CUI>
            <PreferredName>Biogenesis</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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            <RelationSemanticType>Natural Phenomenon or Process</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PART" charOffset="30" text="involved" />
          <Subject charOffset="111" text="COX-1">
            <CUI>C0389003</CUI>
            <PreferredName>cyclooxygenase 1</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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          <Object charOffset="87" text="mitochondrial">
            <CUI>C0026237</CUI>
            <PreferredName>Mitochondria</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PART" charOffset="30" text="involved" />
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            <CUI>C1413634</CUI>
            <PreferredName>COX4I1 gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
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            <RelationSemanticType>Gene or Genome</RelationSemanticType>
          </Subject>
          <Object charOffset="87" text="mitochondrial">
            <CUI>C0026237</CUI>
            <PreferredName>Mitochondria</PreferredName>
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              <SemanticType>Cell Component</SemanticType>
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            <RelationSemanticType>Cell Component</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="207" text="marker" />
          <Subject charOffset="215" text="IGF-I">
            <CUI>C0021665</CUI>
            <PreferredName>Insulin-Like Growth Factor I</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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          <Object charOffset="189" text="mechanical stress">
            <CUI>C0038442</CUI>
            <PreferredName>Stress, Mechanical</PreferredName>
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              <SemanticType>Natural Phenomenon or Process</SemanticType>
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            <RelationSemanticType>Natural Phenomenon or Process</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="16316352">
    <Sentence section="abstract" number="1" text="BACKGROUND: An association between renal hemodynamic dysfunction and coronary artery disease (CAD) has been documented in chronic renal failure; however, no information is available in CAD patients with normal glomerular filtration rate (GFR).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="185" text="CAD">
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            <PreferredName>Coronary Arteriosclerosis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="210" text="glomerular filtration rate">
            <CUI>C0017654</CUI>
            <PreferredName>Glomerular Filtration Rate</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
              <SemanticType>Organ or Tissue Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organ or Tissue Function</RelationSemanticType>
          </Subject>
          <Object charOffset="189" text="patients">
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="118" text="in" />
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            <CUI>C0010054</CUI>
            <PreferredName>Coronary Arteriosclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="122" text="chronic renal failure">
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            <PreferredName>Kidney Failure, Chronic</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="118" text="in" />
          <Subject charOffset="35" text="renal hemodynamic dysfunction">
            <CUI>C0151746</CUI>
            <PreferredName>Abnormal renal function</PreferredName>
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              <SemanticType>Pathologic Function</SemanticType>
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            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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            <PreferredName>Kidney Failure, Chronic</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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      </Predications>
    </Sentence>
    <Sentence section="abstract" number="13" text="CONCLUSION: In CAD patients with normal GFR, reduction in renal perfusion and absence of renal functional reserve likely represent early markers of progressive renal dysfunction.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="15" text="CAD">
            <CUI>C0010054</CUI>
            <PreferredName>Coronary Arteriosclerosis</PreferredName>
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              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="19" text="patients">
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            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="27" text="with" />
          <Subject charOffset="40" text="GFR">
            <CUI>C0017654</CUI>
            <PreferredName>Glomerular Filtration Rate</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
              <SemanticType>Organ or Tissue Function</SemanticType>
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            <RelationSemanticType>Organ or Tissue Function</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16317035">
    <Sentence section="abstract" number="1" text="Cytochrome c6 has long been known as a redox carrier of the thylakoid lumen of cyanobacteria and some eukaryotic algae that can substitute for plastocyanin in electron transfer.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="75" text="of" />
          <Subject charOffset="60" text="thylakoid lumen">
            <CUI>C1622729</CUI>
            <PreferredName>thylakoid lumen</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
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            <RelationSemanticType>Cell Component</RelationSemanticType>
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            <PreferredName>Cyanobacterium</PreferredName>
            <SemanticTypes>
              <SemanticType>Bacterium</SemanticType>
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            <RelationSemanticType>Bacterium</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="75" text="of" />
          <Subject charOffset="60" text="thylakoid lumen">
            <CUI>C1622729</CUI>
            <PreferredName>thylakoid lumen</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
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            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Subject>
          <Object charOffset="113" text="algae">
            <CUI>C0002028</CUI>
            <PreferredName>Algae</PreferredName>
            <SemanticTypes>
              <SemanticType>Alga</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Alga</RelationSemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="113" text="algae">
            <CUI>C0002028</CUI>
            <PreferredName>Algae</PreferredName>
            <SemanticTypes>
              <SemanticType>Alga</SemanticType>
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            <RelationSemanticType>Alga</RelationSemanticType>
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          <Object charOffset="102" text="eukaryotic">
            <CUI>C0684063</CUI>
            <PreferredName>Eukaryota</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism</RelationSemanticType>
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      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16328214">
    <Sentence section="abstract" number="7" text="Findings were confirmed by histological results of a biopsy if rejection, tumor, or acute tubular necrosis were suspected." />
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  <MedlineCitation pmid="16328359">
    <Sentence section="title" number="1" text="Features of the clear zone of odontoclasts in the Chinook salmon (Oncorhynchus tshawytscha).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="42" text="in" />
          <Subject charOffset="30" text="odontoclasts">
            <CUI>C0028876</CUI>
            <PreferredName>Odontoclasts</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="50" text="Chinook salmon">
            <CUI>C0205943</CUI>
            <PreferredName>Oncorhynchus tshawytscha</PreferredName>
            <SemanticTypes>
              <SemanticType>Fish</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fish</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="1" text="This study aims to clarify the features of the clear zone of odontoclasts on shedding teeth of a teleost fish, Chinook salmon, Oncorhynchus tshawytscha (Walbaum), using a light microscope to determine the orientation between a cell body and a resorptive lacuna, followed by transmission electron microscopy.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="73" text="on" />
          <Subject charOffset="61" text="odontoclasts">
            <CUI>C0028876</CUI>
            <PreferredName>Odontoclasts</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="86" text="teeth">
            <CUI>C0040426</CUI>
            <PreferredName>Tooth structure</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="91" text="of" />
          <Subject charOffset="86" text="teeth">
            <CUI>C0040426</CUI>
            <PreferredName>Tooth structure</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="97" text="teleost fish">
            <CUI>C1028265</CUI>
            <PreferredName>teleost fish</PreferredName>
            <SemanticTypes>
              <SemanticType>Fish</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fish</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="109" text="," />
          <Subject charOffset="111" text="Chinook salmon">
            <CUI>C0205943</CUI>
            <PreferredName>Oncorhynchus tshawytscha</PreferredName>
            <SemanticTypes>
              <SemanticType>Fish</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fish</RelationSemanticType>
          </Subject>
          <Object charOffset="97" text="teleost fish">
            <CUI>C1028265</CUI>
            <PreferredName>teleost fish</PreferredName>
            <SemanticTypes>
              <SemanticType>Fish</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fish</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="109" text="," />
          <Subject charOffset="127" text="Oncorhynchus tshawytscha">
            <CUI>C0205943</CUI>
            <PreferredName>Oncorhynchus tshawytscha</PreferredName>
            <SemanticTypes>
              <SemanticType>Fish</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fish</RelationSemanticType>
          </Subject>
          <Object charOffset="97" text="teleost fish">
            <CUI>C1028265</CUI>
            <PreferredName>teleost fish</PreferredName>
            <SemanticTypes>
              <SemanticType>Fish</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fish</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="VERB" charOffset="163" text="using" />
          <Subject charOffset="5" text="study">
            <CUI>C0947630</CUI>
            <PreferredName>Scientific Study</PreferredName>
            <SemanticTypes>
              <SemanticType>Laboratory Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Laboratory Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="171" text="light microscope">
            <CUI>C0491970</CUI>
            <PreferredName>Microscopes, Light</PreferredName>
            <SemanticTypes>
              <SemanticType>Medical Device</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Medical Device</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PRECEDES" indicatorType="PART" charOffset="262" text="followed" />
          <Subject charOffset="171" text="light microscope">
            <CUI>C0491970</CUI>
            <PreferredName>Microscopes, Light</PreferredName>
            <SemanticTypes>
              <SemanticType>Medical Device</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Medical Device</RelationSemanticType>
          </Subject>
          <Object charOffset="274" text="transmission electron microscopy">
            <CUI>C0678118</CUI>
            <PreferredName>Transmission Electron Microscopy</PreferredName>
            <SemanticTypes>
              <SemanticType>Laboratory Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Laboratory Procedure</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16330201">
    <Sentence section="abstract" number="3" text="30-40% epoxy resin adhesive and 50-70% polyurethane, has been developed and used for the first time as the outer protective membrane of the sensor." />
  </MedlineCitation>
  <MedlineCitation pmid="16330236">
    <Sentence section="title" number="1" text="[Ovarian hyperstimulation induced by a GnRH agonist. About one case].">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="26" text="induced" />
          <Subject charOffset="44" text="agonist">
            <CUI>C0243192</CUI>
            <PreferredName>agonists</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="1" text="Ovarian hyperstimulation">
            <CUI>C0549383</CUI>
            <PreferredName>Ovarian hyperstimulation</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16332537">
    <Sentence section="abstract" number="2" text="After eyelid closure in young animals (monocular deprivation, MD), visual cortical neurons become dominated by the open eye, a phenomenon known as ocular dominance (OD) plasticity . ">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="83" text="neurons">
            <CUI>C0027882</CUI>
            <PreferredName>Neurons</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="67" text="visual cortical">
            <CUI>C0042817</CUI>
            <PreferredName>Visual Cortex</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16332961">
    <Sentence section="abstract" number="2" text="The main site for ROS production is the respiratory chain inside the mitochondria and accumulation of mtDNA mutations, and impaired respiratory chain function have been associated with degenerative diseases and aging.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="57" text="inside" />
          <Subject charOffset="69" text="mitochondria">
            <CUI>C0026237</CUI>
            <PreferredName>Mitochondria</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Subject>
          <Object charOffset="40" text="respiratory chain">
            <CUI>C1325653</CUI>
            <PreferredName>Mitochondrial electron transport chain</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="NOM" charOffset="9" text="site" />
          <Subject charOffset="40" text="respiratory chain">
            <CUI>C1325653</CUI>
            <PreferredName>Mitochondrial electron transport chain</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Subject>
          <Object charOffset="18" text="ROS">
            <CUI>C0162772</CUI>
            <PreferredName>Reactive Oxygen Species</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Element, Ion, or Isotope</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="108" text="mutations">
            <CUI>C0026882</CUI>
            <PreferredName>Mutation</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="102" text="mtDNA">
            <CUI>C0012929</CUI>
            <PreferredName>DNA, Mitochondrial</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Nucleic Acid, Nucleoside, or Nucleotide</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="169" text="associated" />
          <Subject charOffset="132" text="respiratory chain">
            <CUI>C0162362</CUI>
            <PreferredName>Respiratory Chain</PreferredName>
            <SemanticTypes>
              <SemanticType>Molecular Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Molecular Function</RelationSemanticType>
          </Subject>
          <Object charOffset="185" text="degenerative diseases">
            <CUI>C1285162</CUI>
            <PreferredName>Degenerative disorder</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="169" text="associated" />
          <Subject charOffset="132" text="respiratory chain">
            <CUI>C0162362</CUI>
            <PreferredName>Respiratory Chain</PreferredName>
            <SemanticTypes>
              <SemanticType>Molecular Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Molecular Function</RelationSemanticType>
          </Subject>
          <Object charOffset="211" text="aging">
            <CUI>C0001811</CUI>
            <PreferredName>Aging</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16338777">
    <Sentence section="abstract" number="1" text="OBJECTIVE: To study the microbial characteristics of patients with pelvic inflammatory disease (PID) and the possible impact of an intrauterine device (IUD) on the microbial environment in women presenting with PID.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="61" text="with" />
          <Subject charOffset="67" text="pelvic inflammatory disease">
            <CUI>C0242172</CUI>
            <PreferredName>Pelvic Inflammatory Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="53" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="VERB" charOffset="195" text="presenting" />
          <Subject charOffset="211" text="PID">
            <CUI>C0242172</CUI>
            <PreferredName>Pelvic Inflammatory Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="189" text="women">
            <CUI>C0043210</CUI>
            <PreferredName>Woman</PreferredName>
            <SemanticTypes>
              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16338878">
    <Sentence section="abstract" number="3" text="Additional findings included paraesophageal hiatus hernia containing squames, urethral atresia, absence of vulva, lung hypoplasia, mild hypoplasia of the corpus callosum, and short umbilical cord with single umbilical artery (SUA).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="146" text="of" />
          <Subject charOffset="154" text="corpus callosum">
            <CUI>C0010090</CUI>
            <PreferredName>Corpus Callosum</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="136" text="hypoplasia">
            <CUI>C0243069</CUI>
            <PreferredName>Hypoplasia</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="195" text="with" />
          <Subject charOffset="175" text="short umbilical cord">
            <CUI>C0266786</CUI>
            <PreferredName>Short cord unspecified</PreferredName>
            <SemanticTypes>
              <SemanticType>Anatomical Abnormality</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Anatomical Abnormality</RelationSemanticType>
          </Subject>
          <Object charOffset="201" text="single umbilical artery">
            <CUI>C1384670</CUI>
            <PreferredName>Single umbilical artery</PreferredName>
            <SemanticTypes>
              <SemanticType>Congenital Abnormality</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Congenital Abnormality</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16339800">
    <Sentence section="abstract" number="7" text="We demonstrate in vitro and in vivo that the ahg3-1 missense mutation causes the loss of PP2C activity, providing concrete confirmation that this PP2C functions as a negative regulator in ABA signaling.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="DISRUPTS" indicatorType="COMPLEX" charOffset="70" text="causes the loss" />
          <Subject charOffset="52" text="missense mutation">
            <CUI>C0599155</CUI>
            <PreferredName>Mutation, Missense</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="89" text="PP2C activity">
            <CUI>C1149927</CUI>
            <PreferredName>protein phosphatase activity</PreferredName>
            <SemanticTypes>
              <SemanticType>Molecular Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Molecular Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="52" text="missense mutation">
            <CUI>C0599155</CUI>
            <PreferredName>Mutation, Missense</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="45" text="ahg3-1">
            <CUI>C1142755</CUI>
            <PreferredName>AHG3 protein, Arabidopsis</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DISRUPTS" indicatorType="NOM" charOffset="166" text="negative regulator" />
          <Subject charOffset="146" text="PP2C">
            <CUI>C0247248</CUI>
            <PreferredName>protein phosphatase 2C</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="192" text="signaling">
            <CUI>C0037083</CUI>
            <PreferredName>Signal Transduction</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="192" text="signaling">
            <CUI>C0037083</CUI>
            <PreferredName>Signal Transduction</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Subject>
          <Object charOffset="188" text="ABA">
            <CUI>C0000843</CUI>
            <PreferredName>Abscisic Acid</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Organic Chemical</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16340726">
    <Sentence section="abstract" number="2" text="METHODS: Dynamic 133Xe SPECT was performed in 34 patients with emphysema and 15 patients with other forms of COPD.">
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        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="VERB" charOffset="33" text="performed" />
          <Subject charOffset="23" text="SPECT">
            <CUI>C0040399</CUI>
            <PreferredName>Tomography, Emission-Computed, Single-Photon</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="49" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="VERB" charOffset="33" text="performed" />
          <Subject charOffset="23" text="SPECT">
            <CUI>C0040399</CUI>
            <PreferredName>Tomography, Emission-Computed, Single-Photon</PreferredName>
            <SemanticTypes>
              <SemanticType>Diagnostic Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Diagnostic Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="80" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="57" text="with" />
          <Subject charOffset="63" text="emphysema">
            <CUI>C0013990</CUI>
            <PreferredName>Pathological accumulation of air in tissues</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Subject>
          <Object charOffset="49" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="88" text="with" />
          <Subject charOffset="109" text="COPD">
            <CUI>C0024117</CUI>
            <PreferredName>Chronic Obstructive Airway Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="80" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16352184">
    <Sentence section="abstract" number="9" text="We used this procedure concomitantly with valve surgery in 84 patients.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="55" text="in" />
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    <Sentence section="abstract" number="9" text="Anteroposterior pelvic radiographs were obtained before and after PCCD application, and after definitive stabilization.">
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            <PreferredName>Plain x-ray</PreferredName>
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              <SemanticType>Population Group</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Postmenopause</PreferredName>
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              <SemanticType>Population Group</SemanticType>
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      </Predications>
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              <SemanticType>Cell</SemanticType>
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              <SemanticType>Cell</SemanticType>
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              <SemanticType>Mammal</SemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Fertilization</PreferredName>
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              <SemanticType>Organism Function</SemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Molecular Function</SemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Phosphatidylinositols</PreferredName>
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        <Predication negated="false" inferred="false">
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    </Sentence>
    <Sentence section="abstract" number="10" text="Erectile function, provided by history and in response to intracavernosal injection and a stimulation test, was significantly diminished in patients with PD and DM (P &lt; 0.05).">
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            <PreferredName>Peyronie Disease</PreferredName>
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            <PreferredName>Diabetes Mellitus</PreferredName>
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            <PreferredName>Diabetic</PreferredName>
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            <PreferredName>Iris nodule</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
          </Subject>
          <Object charOffset="59" text="Langerhans cell histiocytosis">
            <CUI>C0019621</CUI>
            <PreferredName>Histiocytosis, Langerhans-Cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="5" text="RESULTS: An 18-year-old male patient with unilateral anterior segment inflammation and iris nodules experienced visual improvement from 20/200 to 20/25 after treatment with a 5-day course of topical corticosteroids.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="36" text="with" />
          <Subject charOffset="70" text="inflammation">
            <CUI>C0021368</CUI>
            <PreferredName>Inflammation</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="53" text="anterior segment">
            <CUI>C0348014</CUI>
            <PreferredName>Anterior segment</PreferredName>
            <SemanticTypes>
              <SemanticType>Spatial Concept</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Spatial Concept</RelationSemanticType>
          </Subject>
          <Object charOffset="70" text="inflammation">
            <CUI>C0021368</CUI>
            <PreferredName>Inflammation</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="36" text="with" />
          <Subject charOffset="87" text="iris nodules">
            <CUI>C0424839</CUI>
            <PreferredName>Iris nodule</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
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          <Object charOffset="29" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="NOM" charOffset="158" text="treatment" />
          <Subject charOffset="191" text="topical corticosteroids">
            <CUI>C0304604</CUI>
            <PreferredName>Topical form corticosteroids</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="29" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="119" text="improvement" />
          <Subject charOffset="191" text="topical corticosteroids">
            <CUI>C0304604</CUI>
            <PreferredName>Topical form corticosteroids</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="29" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
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          <Subject charOffset="191" text="topical corticosteroids">
            <CUI>C0304604</CUI>
            <PreferredName>Topical form corticosteroids</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="70" text="inflammation">
            <CUI>C0021368</CUI>
            <PreferredName>Inflammation</PreferredName>
            <SemanticTypes>
              <SemanticType>Pathologic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pathologic Function</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
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          <Subject charOffset="191" text="topical corticosteroids">
            <CUI>C0304604</CUI>
            <PreferredName>Topical form corticosteroids</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="87" text="iris nodules">
            <CUI>C0424839</CUI>
            <PreferredName>Iris nodule</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16380233">
    <Sentence section="abstract" number="8" text="In pure cultures, the phospholipid fatty acid (PLFA) composition was strongly influenced by both the carbon source and the growth phase." />
  </MedlineCitation>
  <MedlineCitation pmid="16387100">
    <Sentence section="abstract" number="12" text="Recurrence of glomerulopathy underlying ESRD was frequent for IgAN, FSG, and MCGN, but this was rarely seen in membranous GN.">
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        <Predication negated="false" inferred="false">
          <Predicate type="MANIFESTATION_OF" indicatorType="VERB" charOffset="29" text="underlying" />
          <Subject charOffset="40" text="ESRD">
            <CUI>C1261469</CUI>
            <PreferredName>End stage renal failure</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="14" text="glomerulopathy">
            <CUI>C1398810</CUI>
            <PreferredName>glomerulopathy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="57" text="for" />
          <Subject charOffset="14" text="glomerulopathy">
            <CUI>C1398810</CUI>
            <PreferredName>glomerulopathy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="62" text="IgAN">
            <CUI>C0017661</CUI>
            <PreferredName>IGA Glomerulonephritis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="57" text="for" />
          <Subject charOffset="14" text="glomerulopathy">
            <CUI>C1398810</CUI>
            <PreferredName>glomerulopathy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="68" text="FSG">
            <CUI>C0403425</CUI>
            <PreferredName>Focal segmental glomerulosclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="57" text="for" />
          <Subject charOffset="14" text="glomerulopathy">
            <CUI>C1398810</CUI>
            <PreferredName>glomerulopathy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="77" text="MCGN">
            <CUI>C0017662</CUI>
            <PreferredName>Glomerulonephritis, Membranoproliferative</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PREP" charOffset="107" text="in" />
          <Subject charOffset="14" text="glomerulopathy">
            <CUI>C1398810</CUI>
            <PreferredName>glomerulopathy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="111" text="membranous GN">
            <CUI>C0017665</CUI>
            <PreferredName>Glomerulonephritis, Membranous</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16391093">
    <Sentence section="abstract" number="7" text="For compost and pack treatments, this manure was amended with sawdust or straw to provide an optimal moisture content (60%) for composting for 56 days." />
  </MedlineCitation>
  <MedlineCitation pmid="16394795">
    <Sentence section="abstract" number="10" text="Manometry showed a higher anal sphincter resting pressure and a lower critical volume in food intolerance patients than in the others suffering from constipation unrelated to food intolerance.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="DIAGNOSES" indicatorType="VERB" charOffset="10" text="showed" />
          <Subject charOffset="0" text="Manometry">
            <CUI>C0024751</CUI>
            <PreferredName>Manometry</PreferredName>
            <SemanticTypes>
              <SemanticType>Laboratory Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Laboratory Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="26" text="anal sphincter resting pressure">
            <CUI>C0429217</CUI>
            <PreferredName>Anal sphincter pressure</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Finding</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="89" text="food intolerance">
            <CUI>C0149696</CUI>
            <PreferredName>Food intolerance</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="106" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="VERB" charOffset="134" text="suffering" />
          <Subject charOffset="149" text="constipation">
            <CUI>C0009806</CUI>
            <PreferredName>Constipation</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="106" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="true" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="PART" charOffset="162" text="unrelated" />
          <Subject charOffset="149" text="constipation">
            <CUI>C0009806</CUI>
            <PreferredName>Constipation</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="175" text="food intolerance">
            <CUI>C0149696</CUI>
            <PreferredName>Food intolerance</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="12" text="CONCLUSIONS: Food intolerance-related constipation is characterized by proctitis.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="ADJ" charOffset="30" text="related" />
          <Subject charOffset="13" text="Food intolerance">
            <CUI>C0149696</CUI>
            <PreferredName>Food intolerance</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Subject>
          <Object charOffset="38" text="constipation">
            <CUI>C0009806</CUI>
            <PreferredName>Constipation</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="MANIFESTATION_OF" indicatorType="VERB" charOffset="54" text="characterized" />
          <Subject charOffset="71" text="proctitis">
            <CUI>C0033246</CUI>
            <PreferredName>Proctitis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="38" text="constipation">
            <CUI>C0009806</CUI>
            <PreferredName>Constipation</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16395331">
    <Sentence section="abstract" number="1" text="Cell cycle progression in Caulobacter is driven by the master transcriptional regulators CtrA and GcrA.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="22" text="in" />
          <Subject charOffset="0" text="Cell cycle progression">
            <CUI>C1516334</CUI>
            <PreferredName>Cell Cycle Progression</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Subject>
          <Object charOffset="26" text="Caulobacter">
            <CUI>C0085448</CUI>
            <PreferredName>Caulobacter</PreferredName>
            <SemanticTypes>
              <SemanticType>Bacterium</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Bacterium</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="89" text="CtrA">
            <CUI>C0385936</CUI>
            <PreferredName>CtrA protein, bacteria</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="62" text="transcriptional regulators">
            <CUI>C1336788</CUI>
            <PreferredName>Transcription Regulatory Protein</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="41" text="driven" />
          <Subject charOffset="62" text="transcriptional regulators">
            <CUI>C1336788</CUI>
            <PreferredName>Transcription Regulatory Protein</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="Cell cycle progression">
            <CUI>C1516334</CUI>
            <PreferredName>Cell Cycle Progression</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="AFFECTS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="89" text="CtrA">
            <CUI>C0385936</CUI>
            <PreferredName>CtrA protein, bacteria</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Biologically Active Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="Cell cycle progression">
            <CUI>C1516334</CUI>
            <PreferredName>Cell Cycle Progression</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16402182">
    <Sentence section="abstract" number="5" text="Splenic lymphocytes or purified B-cells obtained from BALB/c mice were cultured with various combinations of IL-4, anti-CD40 antibody, and PAM-extract for 7 days.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="8" text="lymphocytes">
            <CUI>C0024264</CUI>
            <PreferredName>Lymphocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="Splenic">
            <CUI>C0037993</CUI>
            <PreferredName>Spleen</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="48" text="from" />
          <Subject charOffset="8" text="lymphocytes">
            <CUI>C0024264</CUI>
            <PreferredName>Lymphocyte</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="54" text="BALB/c mice">
            <CUI>C0025919</CUI>
            <PreferredName>Mice, Inbred BALB C</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="48" text="from" />
          <Subject charOffset="32" text="B-cells">
            <CUI>C0004561</CUI>
            <PreferredName>B-Lymphocytes</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="54" text="BALB/c mice">
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            <PreferredName>Mice, Inbred BALB C</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="IgE and IgG concentrations of culture supernatants were measured by ELISA." />
  </MedlineCitation>
  <MedlineCitation pmid="16407061">
    <Sentence section="abstract" number="5" text="These reveal the viral morphology with unprecedented clarity and suggest the following mechanism for core formation inside the extracellular virion: core growth initiates at the narrow end of the cone and proceeds toward the distal side of the virion until limited by the viral membrane.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="127" text="extracellular">
            <CUI>C0521119</CUI>
            <PreferredName>Extracellular</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Subject>
          <Object charOffset="141" text="virion">
            <CUI>C0042760</CUI>
            <PreferredName>Virion</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="115" text="inside" />
          <Subject charOffset="141" text="virion">
            <CUI>C0042760</CUI>
            <PreferredName>Virion</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Subject>
          <Object charOffset="101" text="core">
            <CUI>C0598995</CUI>
            <PreferredName>virus core</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DISRUPTS" indicatorType="PART" charOffset="257" text="limited" />
          <Subject charOffset="272" text="viral membrane">
            <CUI>C1167398</CUI>
            <PreferredName>Viral envelope</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Component</RelationSemanticType>
          </Subject>
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            <CUI>C0018270</CUI>
            <PreferredName>Growth</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="154" text="growth">
            <CUI>C0018270</CUI>
            <PreferredName>Growth</PreferredName>
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              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
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          <Object charOffset="149" text="core">
            <CUI>C0598995</CUI>
            <PreferredName>virus core</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16411510">
    <Sentence section="abstract" number="3" text="Our research explored risk factors for participation restrictions experienced by people affected by leprosy.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PART" charOffset="88" text="affected" />
          <Subject charOffset="100" text="leprosy">
            <CUI>C0023343</CUI>
            <PreferredName>Leprosy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="81" text="people">
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            <PreferredName>Persons</PreferredName>
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              <SemanticType>Population Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16411522">
    <Sentence section="title" number="1" text="Treatment of refractory pseudomonas aeruginosa exit-site infection by simultaneous removal and reinsertion of peritoneal dialysis catheter.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="0" text="Treatment" />
          <Subject charOffset="83" text="removal and reinsertion of peritoneal dialysis catheter">
            <CUI>C0204835</CUI>
            <PreferredName>Removal of peritoneal dialysis catheter</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="24" text="pseudomonas aeruginosa exit-site infection">
            <CUI>C0854135</CUI>
            <PreferredName>Pseudomonas aeruginosa infection NOS</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="0" text="Treatment" />
          <Subject charOffset="95" text="reinsertion of peritoneal dialysis catheter">
            <CUI>C0405873</CUI>
            <PreferredName>Insertion of temporary peritoneal dialysis catheter</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
          </Subject>
          <Object charOffset="24" text="pseudomonas aeruginosa exit-site infection">
            <CUI>C0854135</CUI>
            <PreferredName>Pseudomonas aeruginosa infection NOS</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="8" text="RESULTS: Over a 10-year period, 37 CAPD patients underwent the operation.">
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        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="35" text="CAPD">
            <CUI>C0031140</CUI>
            <PreferredName>Peritoneal Dialysis, Continuous Ambulatory</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="40" text="patients">
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            <PreferredName>Patients</PreferredName>
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              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="VERB" charOffset="49" text="underwent" />
          <Subject charOffset="63" text="operation">
            <CUI>C0543467</CUI>
            <PreferredName>Operative Surgical Procedures</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="40" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Patient or Disabled Group</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16412044">
    <Sentence section="title" number="1" text="Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human beta-adrenergic receptor.">
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        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="PART" charOffset="43" text="induced" />
          <Subject charOffset="54" text="active immunization">
            <CUI>C0205991</CUI>
            <PreferredName>Immunization, Active</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="19" text="cardiomyopathic">
            <CUI>C0878544</CUI>
            <PreferredName>Cardiomyopathies</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="NOM" charOffset="61" text="immunization" />
          <Subject charOffset="89" text="synthetic peptide">
            <CUI>C0597551</CUI>
            <PreferredName>synthetic peptide</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="77" text="rats">
            <CUI>C0034721</CUI>
            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="153" text="of" />
          <Subject charOffset="89" text="synthetic peptide">
            <CUI>C0597551</CUI>
            <PreferredName>synthetic peptide</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="167" text="beta-adrenergic receptor">
            <CUI>C0001643</CUI>
            <PreferredName>beta-2 Adrenergic Receptors</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="167" text="beta-adrenergic receptor">
            <CUI>C0001643</CUI>
            <PreferredName>beta-2 Adrenergic Receptors</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="161" text="human">
            <CUI>C0086418</CUI>
            <PreferredName>Homo sapiens</PreferredName>
            <SemanticTypes>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="1" text="In the failing human heart, due to idiopathic dilated cardiomyopathy, it has been suggested that the beta1-adrenergic receptor (beta1AR) is a potential pathogenic autoantigen.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="21" text="heart">
            <CUI>C1281570</CUI>
            <PreferredName>Entire heart</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="15" text="human">
            <CUI>C0086418</CUI>
            <PreferredName>Homo sapiens</PreferredName>
            <SemanticTypes>
              <SemanticType>Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16415554">
    <Sentence section="abstract" number="2" text="One patient was successfully cured by steroid therapy, while the other did not respond to steroid but oral mesalazine was effective.">
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        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="29" text="cured" />
          <Subject charOffset="38" text="steroid therapy">
            <CUI>C0149783</CUI>
            <PreferredName>Steroid therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="4" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="true" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="79" text="respond" />
          <Subject charOffset="90" text="steroid">
            <CUI>C0038317</CUI>
            <PreferredName>Steroids</PreferredName>
            <SemanticTypes>
              <SemanticType>Steroid</SemanticType>
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            <RelationSemanticType>Steroid</RelationSemanticType>
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          <Object charOffset="4" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="ADJ" charOffset="122" text="effective" />
          <Subject charOffset="107" text="mesalazine">
            <CUI>C0360079</CUI>
            <PreferredName>Oral form mesalamine</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="4" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="3" text="Systemic lupus erythematosus is frequently accompanied by gastrointestinal symptoms, but colonic lesions are quite rare, and the regular treatment is not fixed yet.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="COEXISTS_WITH" indicatorType="VERB" charOffset="43" text="accompanied" />
          <Subject charOffset="0" text="Systemic lupus erythematosus">
            <CUI>C0024141</CUI>
            <PreferredName>Lupus Erythematosus, Systemic</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="58" text="gastrointestinal symptoms">
            <CUI>C0426576</CUI>
            <PreferredName>Gastrointestinal symptoms NOS</PreferredName>
            <SemanticTypes>
              <SemanticType>Sign or Symptom</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Sign or Symptom</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="89" text="colonic">
            <CUI>C0009368</CUI>
            <PreferredName>Colon</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="97" text="lesions">
            <CUI>C0221198</CUI>
            <PreferredName>Lesion</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
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            <RelationSemanticType>Finding</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16418362">
    <Sentence section="title" number="1" text="Direct visualization of the human subthalamic nucleus with 3T MR imaging.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="34" text="subthalamic nucleus">
            <CUI>C1281060</CUI>
            <PreferredName>Entire subthalamic nucleus</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="28" text="human">
            <CUI>C0086418</CUI>
            <PreferredName>Homo sapiens</PreferredName>
            <SemanticTypes>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="6" text="METHODS: We performed preoperative stereotactic MR imaging at 3T to visualize the STN in 13 patients undergoing deep-brain stimulation for PD.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="134" text="for" />
          <Subject charOffset="112" text="deep-brain stimulation">
            <CUI>C0394162</CUI>
            <PreferredName>Deep Brain Stimulation</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="139" text="PD">
            <CUI>C0030567</CUI>
            <PreferredName>Parkinson Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ADMINISTERED_TO" indicatorType="VERB" charOffset="101" text="undergoing" />
          <Subject charOffset="112" text="deep-brain stimulation">
            <CUI>C0394162</CUI>
            <PreferredName>Deep Brain Stimulation</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="92" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="85" text="in" />
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            <CUI>C1281060</CUI>
            <PreferredName>Entire subthalamic nucleus</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
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            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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          <Object charOffset="92" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="12" text="CONCLUSION: 3T MR imaging appears to be an excellent tool for reliable and accurate direct visualization of the human STN, necessary for precise surgical targeting.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="118" text="STN">
            <CUI>C1281060</CUI>
            <PreferredName>Entire subthalamic nucleus</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="112" text="human">
            <CUI>C0086418</CUI>
            <PreferredName>Homo sapients</PreferredName>
            <SemanticTypes>
              <SemanticType>Human</SemanticType>
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            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16424791">
    <Sentence section="abstract" number="8" text="Treatment with amlodipine, independently of blood pressure lowering, reduced atherosclerosis development in E3L/CRP mice.">
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        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="104" text="in" />
          <Subject charOffset="77" text="atherosclerosis">
            <CUI>C0004153</CUI>
            <PreferredName>Atherosclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="116" text="mice">
            <CUI>C0026809</CUI>
            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="69" text="reduce" />
          <Subject charOffset="0" text="Treatment">
            <CUI>C0087111</CUI>
            <PreferredName>Therapeutic procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="77" text="atherosclerosis">
            <CUI>C0004153</CUI>
            <PreferredName>Atherosclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="USES" indicatorType="PREP" charOffset="9" text="with" />
          <Subject charOffset="0" text="Treatment">
            <CUI>C0087111</CUI>
            <PreferredName>Therapeutic procedure</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="15" text="amlodipine">
            <CUI>C0051696</CUI>
            <PreferredName>Amlodipine</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="15" text="amlodipine">
            <CUI>C0051696</CUI>
            <PreferredName>Amlodipine</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="77" text="atherosclerosis">
            <CUI>C0004153</CUI>
            <PreferredName>Atherosclerosis</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="112" text="CRP">
            <CUI>C0006560</CUI>
            <PreferredName>C-reactive protein</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Immunologic Factor</RelationSemanticType>
          </Subject>
          <Object charOffset="116" text="mice">
            <CUI>C0026809</CUI>
            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="112" text="CRP">
            <CUI>C0052200</CUI>
            <PreferredName>apolipoprotein E3 (Leidein)</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="116" text="mice">
            <CUI>C0026809</CUI>
            <PreferredName>Mus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16425104">
    <Sentence section="abstract" number="4" text="To test this hypothesis, we investigated the combined effects of environmental conditions and inbreeding on fitness in the self-fertile snail Lymnaea stagnalis, using a stress gradient (0-2) applied to a 100 isolated and paired lineages: laboratory control (0), outdoor microcosm control (1) and pesticide exposure under outdoor microcosm conditions (2).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="142" text="Lymnaea stagnalis">
            <CUI>C0323913</CUI>
            <PreferredName>Lymnaea stagnalis</PreferredName>
            <SemanticTypes>
              <SemanticType>Invertebrate</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Invertebrate</RelationSemanticType>
          </Subject>
          <Object charOffset="136" text="snail">
            <CUI>C0037378</CUI>
            <PreferredName>Snails</PreferredName>
            <SemanticTypes>
              <SemanticType>Invertebrate</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Invertebrate</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="54" text="effects" />
          <Subject charOffset="94" text="inbreeding">
            <CUI>C0021144</CUI>
            <PreferredName>Inbreeding</PreferredName>
            <SemanticTypes>
              <SemanticType>Organism Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Organism Function</RelationSemanticType>
          </Subject>
          <Object charOffset="142" text="Lymnaea stagnalis">
            <CUI>C0323913</CUI>
            <PreferredName>Lymnaea stagnalis</PreferredName>
            <SemanticTypes>
              <SemanticType>Invertebrate</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Invertebrate</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16430036">
    <Sentence section="abstract" number="3" text="Two cycles of freezing--hawing were employed, with apex backward movement when necessary." />
    <Sentence section="abstract" number="8" text="58% of the patients had unilateral prostate cancer, 42% bilateral.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="AUX" charOffset="20" text="had" />
          <Subject charOffset="35" text="prostate cancer">
            <CUI>C0376358</CUI>
            <PreferredName>Malignant neoplasm of prostate</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="11" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="AUX" charOffset="20" text="had" />
          <Subject charOffset="35" text="prostate cancer">
            <CUI>C0376358</CUI>
            <PreferredName>Malignant neoplasm of prostate</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
          </Subject>
          <Object charOffset="11" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="17" text="1 patient suffered injury of the mucosa at the prostatic urethra, which did not result in rectal fistula and was treated with bladder catheter for 3 months.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="25" text="of" />
          <Subject charOffset="33" text="mucosa">
            <CUI>C0026724</CUI>
            <PreferredName>Mucous Membrane</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="injury">
            <CUI>C0175677</CUI>
            <PreferredName>Injury</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="39" text="at" />
          <Subject charOffset="47" text="prostatic urethra">
            <CUI>C0458450</CUI>
            <PreferredName>Prostatic Urethra</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="injury">
            <CUI>C0175677</CUI>
            <PreferredName>Injury</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="VERB" charOffset="10" text="suffered" />
          <Subject charOffset="19" text="injury">
            <CUI>C0175677</CUI>
            <PreferredName>Injury</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
          </Subject>
          <Object charOffset="2" text="patient">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="113" text="treated" />
          <Subject charOffset="126" text="bladder catheter">
            <CUI>C0179802</CUI>
            <PreferredName>Urinary catheter</PreferredName>
            <SemanticTypes>
              <SemanticType>Medical Device</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Medical Device</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="injury">
            <CUI>C0175677</CUI>
            <PreferredName>Injury</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="true" inferred="false">
          <Predicate type="CAUSES" indicatorType="VERB" charOffset="80" text="result" />
          <Subject charOffset="19" text="injury">
            <CUI>C0175677</CUI>
            <PreferredName>Injury</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
          </Subject>
          <Object charOffset="90" text="rectal fistula">
            <CUI>C0034884</CUI>
            <PreferredName>Rectal Fistula</PreferredName>
            <SemanticTypes>
              <SemanticType>Anatomical Abnormality</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Anatomical Abnormality</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16430741">
    <Sentence section="abstract" number="4" text="The aim of this study was to isolate and characterize synovial cells from the human temporomandibular joint (TMJ).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="84" text="temporomandibular joint">
            <CUI>C1269048</CUI>
            <PreferredName>Entire temporomandibular joint</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Subject>
          <Object charOffset="78" text="human">
            <CUI>C0086418</CUI>
            <PreferredName>Homo sapiens</PreferredName>
            <SemanticTypes>
              <SemanticType>Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="68" text="from" />
          <Subject charOffset="54" text="synovial cells">
            <CUI>C0224522</CUI>
            <PreferredName>Synoviocytes</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="84" text="temporomandibular joint">
            <CUI>C1269048</CUI>
            <PreferredName>Entire temporomandibular joint</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16431130">
    <Sentence section="abstract" number="5" text="We here report the implementation of a new, telemetric, infrared-video gaze-tracker to measure visual orienting in freely moving, socially housed prosimian primates (Lemur catta).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="146" text="prosimian">
            <CUI>C0086861</CUI>
            <PreferredName>Prosimii</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Subject>
          <Object charOffset="156" text="primates">
            <CUI>C0033147</CUI>
            <PreferredName>Primates</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="165" text="(" />
          <Subject charOffset="166" text="Lemur catta">
            <CUI>C0324779</CUI>
            <PreferredName>Lemur catta</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Subject>
          <Object charOffset="146" text="prosimian">
            <CUI>C0086861</CUI>
            <PreferredName>Prosimii</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16436670">
    <Sentence section="abstract" number="4" text="IFN-alpha profoundly alters cytoskeletal organization of hairy cells and causes reversion of the hairy appearance into a rounded morphology.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="VERB" charOffset="21" text="alters" />
          <Subject charOffset="0" text="IFN-alpha">
            <CUI>C1610033</CUI>
            <PreferredName>Interferon Alpha, Human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="28" text="cytoskeletal organization">
            <CUI>C1511632</CUI>
            <PreferredName>Cytoskeletal Modeling</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="53" text="of" />
          <Subject charOffset="57" text="hairy cells">
            <CUI>C0333850</CUI>
            <PreferredName>Hairy cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="28" text="cytoskeletal organization">
            <CUI>C1511632</CUI>
            <PreferredName>Cytoskeletal Modeling</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell Function</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="5" text="Because cytoskeletal rearrangements are controlled by the Rho family of GTPases, we investigated the GTPase activation status in hairy cells and their regulation by IFN-alpha.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="NOM" charOffset="151" text="regulation" />
          <Subject charOffset="165" text="IFN-alpha">
            <CUI>C1610033</CUI>
            <PreferredName>Interferon Alpha, Human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="101" text="GTPase">
            <CUI>C0018296</CUI>
            <PreferredName>Guanosine Triphosphate Phosphohydrolases</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="125" text="in" />
          <Subject charOffset="129" text="hairy cells">
            <CUI>C0333850</CUI>
            <PreferredName>Hairy cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="101" text="GTPase">
            <CUI>C0018296</CUI>
            <PreferredName>Guanosine Triphosphate Phosphohydrolases</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="7" text="In sharp contrast, RhoA activity was low in hairy cells but was increased by IFN-alpha treatment.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="40" text="in" />
          <Subject charOffset="44" text="hairy cells">
            <CUI>C0333850</CUI>
            <PreferredName>Hairy cell</PreferredName>
            <SemanticTypes>
              <SemanticType>Cell</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Cell</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="RhoA">
            <CUI>C0812234</CUI>
            <PreferredName>RHOA gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="387" name="RHOA" />
            </EntrezGene>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="STIMULATES" indicatorType="VERB" charOffset="64" text="increased" />
          <Subject charOffset="77" text="IFN-alpha">
            <CUI>C1610033</CUI>
            <PreferredName>Interferon Alpha, Human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
          </Subject>
          <Object charOffset="19" text="RhoA">
            <CUI>C0812234</CUI>
            <PreferredName>RHOA gene</PreferredName>
            <SemanticTypes>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="387" name="RHOA" />
            </EntrezGene>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16440178">
    <Sentence section="abstract" number="1" text="The secretion of uterine luminal fluid initially provides a transport and support medium for spermatozoa and unimplanted embryos, while the absorption of uterine luminal fluid in early pregnancy results in the closure of the lumen and allows blastocysts to establish intimate contact with the uterine epithelium.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="301" text="epithelium">
            <CUI>C0014609</CUI>
            <PreferredName>Epithelium</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
          </Subject>
          <Object charOffset="293" text="uterine">
            <CUI>C0042149</CUI>
            <PreferredName>Uterus</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16441715">
    <Sentence section="title" number="1" text="Is a dual-sensor pacemaker appropriate in patients with sino-atrial disease?">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="50" text="with" />
          <Subject charOffset="56" text="sino-atrial disease">
            <CUI>C0037188</CUI>
            <PreferredName>Sinoatrial Block</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
          </Subject>
          <Object charOffset="42" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="38" text="in" />
          <Subject charOffset="17" text="pacemaker">
            <CUI>C0030163</CUI>
            <PreferredName>Artificial cardiac pacemaker</PreferredName>
            <SemanticTypes>
              <SemanticType>Medical Device</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Medical Device</RelationSemanticType>
          </Subject>
          <Object charOffset="42" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
  </MedlineCitation>
  <MedlineCitation pmid="16445747">
    <Sentence section="title" number="1" text="Promoters and their regulation in Ustilago maydis and other phytopathogenic fungi.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="30" text="in" />
          <Subject charOffset="34" text="Ustilago maydis">
            <CUI>C0446013</CUI>
            <PreferredName>Ustilago maydis</PreferredName>
            <SemanticTypes>
              <SemanticType>Fungus</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fungus</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="Promoters">
            <CUI>C0086860</CUI>
            <PreferredName>Promoter (Genetics)</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Object>
        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="30" text="in" />
          <Subject charOffset="76" text="fungi">
            <CUI>C0016832</CUI>
            <PreferredName>fungus</PreferredName>
            <SemanticTypes>
              <SemanticType>Fungus</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Fungus</RelationSemanticType>
          </Subject>
          <Object charOffset="0" text="Promoters">
            <CUI>C0086860</CUI>
            <PreferredName>Promoter (Genetics)</PreferredName>
            <SemanticTypes>
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  <MedlineCitation pmid="16460640">
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        <Predication negated="false" inferred="false">
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              <SemanticType>Injury or Poisoning</SemanticType>
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      </Predications>
    </Sentence>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Finding</SemanticType>
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              <SemanticType>Cell Component</SemanticType>
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              <SemanticType>Gene or Genome</SemanticType>
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            <PreferredName>DUSP1 gene</PreferredName>
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              <SemanticType>Gene or Genome</SemanticType>
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            <RelationSemanticType>Gene or Genome</RelationSemanticType>
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              <EntrezGeneTerm id="1843" name="DUSP1" />
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              <SemanticType>Cell Function</SemanticType>
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            <RelationSemanticType>Cell Function</RelationSemanticType>
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              <SemanticType>Cell Function</SemanticType>
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            <PreferredName>Mus</PreferredName>
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              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="16470169">
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        <Predication negated="false" inferred="false">
          <Predicate type="STIMULATES" indicatorType="VERB" charOffset="59" text="activate" />
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            <CUI>C0073185</CUI>
            <PreferredName>rho</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Immunologic Factor</SemanticType>
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              <EntrezGeneTerm id="29984" name="RHOD" />
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            <PreferredName>1-Phosphatidylinositol 3-Kinase</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="STIMULATES" indicatorType="VERB" charOffset="59" text="activate" />
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            <PreferredName>rho</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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              <EntrezGeneTerm id="6010" name="RHO" />
              <EntrezGeneTerm id="29984" name="RHOD" />
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            <CUI>C0164786</CUI>
            <PreferredName>Proto-Oncogene Proteins c-akt</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Enzyme</SemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="INHIBITS" indicatorType="VERB" charOffset="74" text="downregulate" />
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            <PreferredName>rho</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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              <EntrezGeneTerm id="6010" name="RHO" />
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            <CUI>C0044602</CUI>
            <PreferredName>1-Phosphatidylinositol 3-Kinase</PreferredName>
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              <SemanticType>Enzyme</SemanticType>
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        <Predication negated="false" inferred="false">
          <Predicate type="INHIBITS" indicatorType="VERB" charOffset="74" text="downregulate" />
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            <PreferredName>rho</PreferredName>
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              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
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  <MedlineCitation pmid="16470989">
    <Sentence section="abstract" number="7" text="DISCUSSION: Hierarchic severity levels, sum score of disability, and preceding changes in disability status are risk factors for depressive symptoms." />
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  <MedlineCitation pmid="16479855">
    <Sentence section="abstract" number="9" text="Balloon dilatation resulted in complete elimination of the stricture in 44/82 (54%) and a reduction in the stricture in 32/82 (39%) and no improvement in 6/82 (7%).">
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        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="40" text="elimination" />
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            <PreferredName>Balloon Dilatation</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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              <SemanticType>Anatomical Abnormality</SemanticType>
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            <RelationSemanticType>Anatomical Abnormality</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Balloon Dilatation</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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              <SemanticType>Anatomical Abnormality</SemanticType>
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            <RelationSemanticType>Anatomical Abnormality</RelationSemanticType>
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        <Predication negated="true" inferred="false">
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            <PreferredName>Balloon Dilatation</PreferredName>
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Congenital Abnormality</SemanticType>
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        <Predication negated="true" inferred="false">
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          <Subject charOffset="68" text="non-Down syndrome">
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            <PreferredName>Down Syndrome</PreferredName>
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              <SemanticType>Congenital Abnormality</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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              <SemanticType>Mental or Behavioral Dysfunction</SemanticType>
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            <RelationSemanticType>Mental or Behavioral Dysfunction</RelationSemanticType>
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            <PreferredName>Vagina</PreferredName>
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              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
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            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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              <SemanticType>Receptor</SemanticType>
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            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
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            <PreferredName>Body tissue</PreferredName>
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              <SemanticType>Tissue</SemanticType>
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            <RelationSemanticType>Tissue</RelationSemanticType>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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        <Predication negated="false" inferred="false">
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            <PreferredName>Body tissue</PreferredName>
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              <SemanticType>Tissue</SemanticType>
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            <PreferredName>Bitch</PreferredName>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="42" text="is" />
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            <PreferredName>Venereal Tumors, Veterinary</PreferredName>
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            <PreferredName>Neoplasm</PreferredName>
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          <Subject charOffset="49" text="transmissible venereal tumor">
            <CUI>C0042465</CUI>
            <PreferredName>Venereal Tumors, Veterinary</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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            <CUI>C0012984</CUI>
            <PreferredName>Canis familiaris</PreferredName>
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        <Predication negated="false" inferred="false">
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          <Subject charOffset="49" text="transmissible venereal tumor">
            <CUI>C0042465</CUI>
            <PreferredName>Venereal Tumors, Veterinary</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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          <Object charOffset="116" text="female genital tract">
            <CUI>C0017421</CUI>
            <PreferredName>Female genitalia</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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    <Sentence section="abstract" number="8" text="Although some samples had expression in the endothelium of blood vessels, no ER-alpha expression was observed in neoplastic tissues.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="55" text="of" />
          <Subject charOffset="44" text="endothelium">
            <CUI>C0014257</CUI>
            <PreferredName>Endothelium</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
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            <RelationSemanticType>Tissue</RelationSemanticType>
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            <CUI>C0005847</CUI>
            <PreferredName>Blood Vessels</PreferredName>
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              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
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            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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          <Predicate type="LOCATION_OF" indicatorType="PREP" charOffset="109" text="in" />
          <Subject charOffset="124" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Tissue</RelationSemanticType>
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          <Object charOffset="77" text="ER-alpha">
            <CUI>C1521863</CUI>
            <PreferredName>ESR1 protein, human</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Receptor</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Amino Acid, Peptide, or Protein</RelationSemanticType>
            <EntrezGene>
              <EntrezGeneTerm id="2099" name="ESR1" />
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="113" text="neoplastic">
            <CUI>C0027651</CUI>
            <PreferredName>Neoplasm</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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          <Object charOffset="124" text="tissues">
            <CUI>C0040300</CUI>
            <PreferredName>Body tissue</PreferredName>
            <SemanticTypes>
              <SemanticType>Tissue</SemanticType>
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            <RelationSemanticType>Tissue</RelationSemanticType>
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        </Predication>
      </Predications>
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  <MedlineCitation pmid="16496259">
    <Sentence section="abstract" number="13" text="Five eyes (7%) had transient increase of IOP controlled by topical antiglaucomatous medications.">
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        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="PART" charOffset="45" text="controlled" />
          <Subject charOffset="84" text="medications">
            <CUI>C0013227</CUI>
            <PreferredName>Pharmaceutical Preparations</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="41" text="IOP">
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            <PreferredName>Physiologic Intraocular Pressure</PreferredName>
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              <SemanticType>Organ or Tissue Function</SemanticType>
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            <RelationSemanticType>Organ or Tissue Function</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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          <Subject charOffset="84" text="medications">
            <CUI>C0013227</CUI>
            <PreferredName>Pharmaceutical Preparations</PreferredName>
            <SemanticTypes>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="67" text="antiglaucomatous">
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            <PreferredName>Glaucoma</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="AUX" charOffset="15" text="had" />
          <Subject charOffset="5" text="eyes">
            <CUI>C0015392</CUI>
            <PreferredName>Eyes</PreferredName>
            <SemanticTypes>
              <SemanticType>Body Part, Organ, or Organ Component</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Body Part, Organ, or Organ Component</RelationSemanticType>
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          <Object charOffset="41" text="IOP">
            <CUI>C0021888</CUI>
            <PreferredName>Physiologic Intraocular Pressure</PreferredName>
            <SemanticTypes>
              <SemanticType>Organ or Tissue Function</SemanticType>
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            <RelationSemanticType>Organ or Tissue Function</RelationSemanticType>
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      </Predications>
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  <MedlineCitation pmid="16496495">
    <Sentence section="abstract" number="9" text="Organophosphates were implicated in 70.9% of all fatalities, with over 20% resulting from oral exposure to rat poison (RP).">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="111" text="poison">
            <CUI>C0032346</CUI>
            <PreferredName>Poisons</PreferredName>
            <SemanticTypes>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Hazardous or Poisonous Substance</RelationSemanticType>
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          <Object charOffset="107" text="rat">
            <CUI>C0034721</CUI>
            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Mammal</RelationSemanticType>
          </Object>
        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="10" text="CONCLUSION: Organophosphates and rat poison (RP) are the leading causes of APP admissions to major referral hospitals in Zimbabwe, with most of the admissions being the result of deliberate self-poisoning.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="NOM" charOffset="65" text="causes" />
          <Subject charOffset="12" text="Organophosphates">
            <CUI>C1452958</CUI>
            <PreferredName>Organophosphates</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
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            <RelationSemanticType>Organic Chemical</RelationSemanticType>
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          <Object charOffset="75" text="APP">
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            <PreferredName>Pesticide poisoning</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
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            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="CAUSES" indicatorType="NOM" charOffset="65" text="causes" />
          <Subject charOffset="37" text="poison">
            <CUI>C0032346</CUI>
            <PreferredName>Poisons</PreferredName>
            <SemanticTypes>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Hazardous or Poisonous Substance</RelationSemanticType>
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          <Object charOffset="75" text="APP">
            <CUI>C0275009</CUI>
            <PreferredName>Pesticide poisoning</PreferredName>
            <SemanticTypes>
              <SemanticType>Injury or Poisoning</SemanticType>
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            <RelationSemanticType>Injury or Poisoning</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AFFECTS" indicatorType="MOD_HEAD" charOffset="" text="" />
          <Subject charOffset="37" text="poison">
            <CUI>C0032346</CUI>
            <PreferredName>Poisons</PreferredName>
            <SemanticTypes>
              <SemanticType>Hazardous or Poisonous Substance</SemanticType>
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            <RelationSemanticType>Hazardous or Poisonous Substance</RelationSemanticType>
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          <Object charOffset="33" text="rat">
            <CUI>C0034721</CUI>
            <PreferredName>Rattus</PreferredName>
            <SemanticTypes>
              <SemanticType>Mammal</SemanticType>
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            <RelationSemanticType>Mammal</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16498946">
    <Sentence section="abstract" number="3" text="In Gilbert's syndrome, genetic alterations are located at the promoter of the gene and accompanied by the nucleotide insert of thymine adenine (TA).">
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        <Predication negated="false" inferred="false">
          <Predicate type="PART_OF" indicatorType="PREP" charOffset="70" text="of" />
          <Subject charOffset="62" text="promoter">
            <CUI>C0086860</CUI>
            <PreferredName>Promoter (Genetics)</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="78" text="gene">
            <CUI>C0017337</CUI>
            <PreferredName>Genes</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Gene or Genome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="LOCATION_OF" indicatorType="VERB" charOffset="47" text="located" />
          <Subject charOffset="62" text="promoter">
            <CUI>C0086860</CUI>
            <PreferredName>Promoter (Genetics)</PreferredName>
            <SemanticTypes>
              <SemanticType>Biologically Active Substance</SemanticType>
              <SemanticType>Nucleic Acid, Nucleoside, or Nucleotide</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Biologically Active Substance</RelationSemanticType>
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          <Object charOffset="23" text="genetic alterations">
            <CUI>C0026882</CUI>
            <PreferredName>Mutation</PreferredName>
            <SemanticTypes>
              <SemanticType>Genetic Function</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Genetic Function</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16503396">
    <Sentence section="abstract" number="11" text="Combined treatment improves overall and disease-free survival in patients with stage II, III and IVA oral tongue cancer.">
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        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="PREP" charOffset="61" text="in" />
          <Subject charOffset="0" text="Combined treatment">
            <CUI>C0009429</CUI>
            <PreferredName>Combined Modality Therapy</PreferredName>
            <SemanticTypes>
              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Therapeutic or Preventive Procedure</RelationSemanticType>
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          <Object charOffset="65" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="PROCESS_OF" indicatorType="PREP" charOffset="73" text="with" />
          <Subject charOffset="106" text="tongue cancer">
            <CUI>C0153349</CUI>
            <PreferredName>Malignant neoplasm of tongue</PreferredName>
            <SemanticTypes>
              <SemanticType>Neoplastic Process</SemanticType>
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            <RelationSemanticType>Neoplastic Process</RelationSemanticType>
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          <Object charOffset="65" text="patients">
            <CUI>C0030705</CUI>
            <PreferredName>Patients</PreferredName>
            <SemanticTypes>
              <SemanticType>Patient or Disabled Group</SemanticType>
              <SemanticType>Human</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Human</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
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  <MedlineCitation pmid="16503761">
    <Sentence section="abstract" number="1" text="Thiazolidinediones (TZDs) are peroxisomal proliferator-activated receptor (PPAR)-gamma agonists.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="STIMULATES" indicatorType="NOM" charOffset="87" text="agonists" />
          <Subject charOffset="0" text="Thiazolidinediones">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Organic Chemical</RelationSemanticType>
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          <Object charOffset="30" text="peroxisomal proliferator-activated receptor (PPAR)-gamma">
            <CUI>C0166417</CUI>
            <PreferredName>PPAR gamma</PreferredName>
            <SemanticTypes>
              <SemanticType>Amino Acid, Peptide, or Protein</SemanticType>
              <SemanticType>Gene or Genome</SemanticType>
              <SemanticType>Receptor</SemanticType>
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            <RelationSemanticType>Gene or Genome</RelationSemanticType>
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        </Predication>
      </Predications>
    </Sentence>
    <Sentence section="abstract" number="7" text="Other, as yet, unapproved uses of TZDs include: non-alcoholic fatty liver disease, in which TZDs reduced hepatic fat accumulation and improved liver function tests; polycystic ovary syndrome, where TZDs improved ovulation, hirsutism and endothelial dysfunction; and lipodystrophies, where TZDs increased body fat (marginally) and decrease liver size.">
      <Predications>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="26" text="uses" />
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            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="ISA" indicatorType="SPEC" charOffset="" text="" />
          <Subject charOffset="48" text="non-alcoholic fatty liver">
            <CUI>C0400966</CUI>
            <PreferredName>Non-alcoholic fatty liver</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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          <Object charOffset="74" text="disease">
            <CUI>C0012634</CUI>
            <PreferredName>Disease</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication inferred="true" negated="false">
          <Predicate type="TREATS" indicatorType="INFER" charOffset="" text="" />
          <Subject charOffset="34" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="48" text="non-alcoholic fatty liver">
            <CUI>C0400966</CUI>
            <PreferredName>Non-alcoholic fatty liver</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="DISRUPTS" indicatorType="VERB" charOffset="97" text="reduced" />
          <Subject charOffset="92" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="105" text="hepatic fat accumulation">
            <CUI>C0151765</CUI>
            <PreferredName>Liver fatty deposition</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
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            <RelationSemanticType>Finding</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
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          <Subject charOffset="34" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="165" text="polycystic ovary syndrome">
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            <PreferredName>Polycystic Ovary Syndrome</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="AUGMENTS" indicatorType="VERB" charOffset="203" text="improved" />
          <Subject charOffset="198" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
          </Subject>
          <Object charOffset="212" text="ovulation">
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            <PreferredName>Ovulation</PreferredName>
            <SemanticTypes>
              <SemanticType>Organ or Tissue Function</SemanticType>
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            <RelationSemanticType>Organ or Tissue Function</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="203" text="improved" />
          <Subject charOffset="198" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
            </SemanticTypes>
            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="223" text="hirsutism">
            <CUI>C0019572</CUI>
            <PreferredName>Hirsutism</PreferredName>
            <SemanticTypes>
              <SemanticType>Finding</SemanticType>
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            <RelationSemanticType>Finding</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="VERB" charOffset="203" text="improved" />
          <Subject charOffset="198" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
            <SemanticTypes>
              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="237" text="endothelial dysfunction">
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            <PreferredName>Endothelial dysfunction</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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        </Predication>
        <Predication negated="false" inferred="false">
          <Predicate type="TREATS" indicatorType="NOM" charOffset="26" text="uses" />
          <Subject charOffset="34" text="TZDs">
            <CUI>C1257987</CUI>
            <PreferredName>Thiazolidinediones</PreferredName>
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              <SemanticType>Organic Chemical</SemanticType>
              <SemanticType>Pharmacologic Substance</SemanticType>
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            <RelationSemanticType>Pharmacologic Substance</RelationSemanticType>
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          <Object charOffset="266" text="lipodystrophies">
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            <PreferredName>Lipodystrophy</PreferredName>
            <SemanticTypes>
              <SemanticType>Disease or Syndrome</SemanticType>
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            <RelationSemanticType>Disease or Syndrome</RelationSemanticType>
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            <PreferredName>Thiazolidinediones</PreferredName>
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            <PreferredName>Liver size</PreferredName>
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              <SemanticType>Finding</SemanticType>
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            <PreferredName>Copper</PreferredName>
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              <SemanticType>Biologically Active Substance</SemanticType>
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            <PreferredName>collagen type IV alpha5 subunit, human</PreferredName>
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              <SemanticType>Cell</SemanticType>
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            <PreferredName>Body tissue</PreferredName>
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              <SemanticType>Tissue</SemanticType>
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            <PreferredName>Colorectal Neoplasms</PreferredName>
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              <SemanticType>Cell</SemanticType>
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            <RelationSemanticType>Cell</RelationSemanticType>
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            <PreferredName>Colon Carcinoma</PreferredName>
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              <SemanticType>Neoplastic Process</SemanticType>
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  <MedlineCitation pmid="16510729">
    <Sentence section="abstract" number="1" text="The dopamine D3 receptor, which is highly enriched in nucleus accumbens (NAc), has been suggested to play an important role in reinforcement and reward.">
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        <Predication negated="false" inferred="false">
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            <PreferredName>Nucleus Accumbens</PreferredName>
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        <Predication negated="false" inferred="false">
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              <SemanticType>Therapeutic or Preventive Procedure</SemanticType>
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            <RelationSemanticType>Mental Process</RelationSemanticType>
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  <MedlineCitation pmid="15561572">
    <Sentence section="abstract" number="7" text="The molar relaxivity of PTIR267 in saline is 26 mM(-1)s(-1)." />
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            <PreferredName>DNA Sequence</PreferredName>
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